With recent studies using genetic, epigenetic, and other molecular and neurochemical
approaches, a new era has begun in understanding pathophysiology of suicide. Emerging …

Abstract Serotonin (5HT) modulates the stress response by interacting with the hormonal
hypothalamic–pituitary–adrenal (HPA) axis and neuronal sympathetic nervous system …

Approximately 1 million people worldwide die by suicide each year. With a prevalence rate
of 0.0145% and suicide accounting for 1.5% of death by all causes, it is the 10th leading …

Background Several lines of evidence from previous research indicate that opioid receptors
play an important role in ethanol reinforcement and alcohol dependence (AD) risk …

Background: Antidepressant medication is a major cornerstone in treatment of mood and
anxiety disorders. Numerous substances are available on the market; however, only 60% of …

The association of single-nucleotide polymorphisms (SNPs) in the human tryptophan
hydroxylase 2 (TPH2) gene with anxiety traits and depression has been inconclusive …

Abstract Serotonin (5HT) is a neurotransmitter involved in many aspects of the neuronal
function. The synthesis of 5HT is initiated by the hydroxylation of tryptophan, catalyzed by …

Suicide is thought to result from the harmful interaction of multiple factors that have social,
environmental, neurobiological, and genetic backgrounds. Recent studies have suggested …

OBJECTIVES: Hopelessness is one of the strongest risk factors for suicidal behavior but
relevant genetic studies are poorly available. Tryptophan hydroxylase (TPH) is widely …

Every year over 1 million people commit and over 10 million people attempt suicide. This is
one suicide every 40s and one suicide attempt every 3s worldwide. Suicide accounts for …