Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

R Faner, M Rojas, W MacNee… - American journal of …, 2012 - atsjournals.org
Aging is a natural process characterized by progressive functional impairment and reduced
capacity to respond appropriately to environmental stimuli and injury. The incidence of two …

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13

MH Cho, PJ Castaldi, ES Wan… - Human molecular …, 2012 - academic.oup.com
The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely
unknown. To date, genome-wide association studies (GWASs) of limited size have identified …

Understanding the natural progression in% FEV1 decline in patients with cystic fibrosis: a longitudinal study

D Taylor-Robinson, M Whitehead, F Diderichsen… - Thorax, 2012 - thorax.bmj.com
Background Forced expiratory volume in 1 s as a percentage of predicted (% FEV1) is a key
outcome in cystic fibrosis (CF) and other lung diseases. As people with CF survive for longer …

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function

DB Hancock, MS Artigas, SA Gharib, A Henry… - PLoS …, 2012 - journals.plos.org
Genome-wide association studies have identified numerous genetic loci for spirometic
measures of pulmonary function, forced expiratory volume in one second (FEV1), and its …

[HTML][HTML] Guía de Práctica Clínica para el diagnóstico y tratamiento de pacientes con enfermedad pulmonar obstructiva crónica (EPOC)-Guía Española de la EPOC …

GT de GesEPOC, TF of GesEPOC - Archivos de …, 2012 - ncbi.nlm.nih.gov
La enfermedad pulmonar obstructiva crónica (EPOC) se caracteriza esencialmente por una
limitación crónica al flujo aéreo poco reversible y asociada principalmente al humo de …

[HTML][HTML] Is there a lower limit of pretreatment pulmonary function for safe and effective stereotactic body radiotherapy for early-stage non-small cell lung cancer?

M Guckenberger, LL Kestin, AJ Hope… - Journal of Thoracic …, 2012 - Elsevier
Introduction To evaluate the influence of pretreatment pulmonary function (PF) on survival,
early and late pulmonary toxicity after stereotactic body radiotherapy (SBRT) for early-stage …

Serial computed tomography and lung function testing in pulmonary Langerhans' cell histiocytosis

A Tazi, K Marc, S Dominique… - European …, 2012 - Eur Respiratory Soc
Little is known about longitudinal lung function variation in patients with pulmonary
Langerhans' cell histiocytosis (LCH). The contribution of serial lung computed tomography …

Antibiotics as immunomodulant agents in COPD

F Blasi, M Mantero, S Aliberti - Current opinion in pharmacology, 2012 - Elsevier
It is widely accepted that some antibiotics have activities beyond their direct antibacterial
effects. Macrolide is the antibiotic class with more convincing studies and evidence on its …

Combined effect of lung function level and decline increases morbidity and mortality risks

P Baughman, JL Marott, P Lange, CJ Martin… - European journal of …, 2012 - Springer
Lung function level and decline are each predictive of morbidity and mortality. Evaluation of
the combined effect of these measurements may help further identify high-risk groups. Using …

Asthma in the elderly

A Gillman, JA Douglass - Asia Pacific Allergy, 2012 - journals.lww.com
As the population increases in age, the diseases of older age will have increasing
prevalence and place a greater burden on the health system. Despite asthma being usually …