Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress

BS McEwen, L Eiland, RG Hunter, MM Miller - Neuropharmacology, 2012 - Elsevier
The brain is the central organ of stress and adaptation to stress because it perceives and
determines what is threatening, as well as the behavioral and physiological responses to the …

Age, experience, injury, and the changing brain

B Kolb, GC Teskey - Developmental psychobiology, 2012 - Wiley Online Library
The fundamental concept in the emerging field of rehabilitation and brain plasticity is that
although there is much constancy in brain function and organization across our lifetime …

Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity

SL Gourley, A Olevska, MS Warren… - Journal of …, 2012 - Soc Neuroscience
Adolescence is characterized by vulnerability to the development of neuropsychiatric
disorders including drug addiction, as well as prefrontal cortical refinement that culminates …

Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications

AR Wolen, CA Phillips, MA Langston, AH Putman… - PloS one, 2012 - journals.plos.org
Background Individual differences in initial sensitivity to ethanol are strongly related to the
heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate …

Selective effects of perinatal ethanol exposure in medial prefrontal cortex and nucleus accumbens

RC Lawrence, NKH Otero, SJ Kelly - Neurotoxicology and teratology, 2012 - Elsevier
Ethanol exposure during development is the leading known cause of mental retardation and
can result in characteristic physiological and cognitive deficits, often termed Fetal Alcohol …

Mechanisms of psychostimulant-induced structural plasticity

SA Golden, SJ Russo - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Psychostimulants robustly induce alterations in neuronal structural plasticity throughout
brain reward circuits. However, despite our extensive understanding of how these circuits …

Abnormal striatal circuitry and intensified novelty seeking among adolescents who abuse methamphetamine and cannabis

JC Churchwell, PD Carey, HL Ferrett, DJ Stein… - Developmental …, 2012 - karger.com
It has been hypothesized that changes in striatal-mediated dopamine modulation during
adolescence may increase the risk for initiating substance abuse as a result of its …

Chronic administration of the neurotrophic agent cerebrolysin ameliorates the behavioral and morphological changes induced by neonatal ventral hippocampus …

RA Vázquez‐Roque, B Ramos… - Journal of …, 2012 - Wiley Online Library
Neonatal ventral hippocampal lesion (nVHL) in rats has been widely used as a
neurodevelopmental model to mimic schizophrenia‐like behaviors. Recently, we reported …

Combined administration of cerebrolysin and donepezil induces plastic changes in prefrontal cortex in aged mice

F Alcántara‐González, CR Mendoza‐Perez… - Synapse, 2012 - Wiley Online Library
Cerebrolysin (Cbl) shows neurotrophic and neuroprotective properties while donepezil
(Dnp) is a potent acetylcholinesterase (AChE) inhibitor, both drugs are prescribed for …

Dendritic morphology in the striatum and hypothalamus differentially exhibits experience-dependent changes in response to maternal care and early social isolation

S Shams, JL Pawluski… - Behavioural brain …, 2012 - Elsevier
Changes in neuron morphology, stemming from experiences in early life or adulthood, may
be the basis for changes in behavior and their underlying functional mechanisms. For …