Viruses are intracellular pathogens responsible for a vast number of human diseases. Due
to their small genome size, viruses rely primarily on the biosynthetic apparatus of the host for …

Epigenetics refers to alterations in gene expression due to modifications in histone
acetylation and DNA methylation at the promoter regions of genes. Unlike genetic mutations …

Since their discovery by Bangham about 50 years ago, liposomes have become promising
tools in drug delivery systems. This has increased the therapeutic index of many drugs, and …

The AML1-ETO fusion transcription factor is generated by the t (8; 21) translocation, which is
present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid …

In preclinical models, the histone deacetylase inhibitor vorinostat sensitizes breast cancer
cells to tubulin-polymerizing agents and to anti-vascular endothelial growth factor-directed …

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are two opposing
classes of enzymes, which finely regulate the balance of histone acetylation affecting …

At present no successful treatment is available for advanced thyroid cancer, which
comprises poorly differentiated, anaplastic, and metastatic or recurrent differentiated thyroid …

Objective: To investigate the relationship between cisplatin resistance and histone
deacetylase (HDAC) isoform overexpression in ovarian cancer cell lines. Methods …

Epigenetic mechanisms may contribute to drug resistance by interfering with tumor growth
regulatory pathways and pro-apoptotic programs. Since gene expression is regulated by …

We synthesized a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI),
CG200745 {(E)-2-(Naphthalen-1-yloxymethyl)-oct-2-enedioic acid 1-[(3-dimethylamino …