The advent of unbiased recording and imaging techniques to evaluate firing activity across
neocortical neurons has revealed substantial heterogeneity in response properties in vivo …

The innate immune system is comprised of cellular sentinels that often serve as the first
responders to injury and invading pathogens. Our basic understanding of innate immunity is …

Summary The Arc/Arg3. 1 gene product is rapidly upregulated by strong synaptic activity and
critically contributes to weakening synapses by promoting AMPA-R endocytosis. However …

Nuclear factor of activated T cells (NFAT) is a calcium-responsive transcription factor. We
describe here an NFAT-based neural tracing method—CaLexA (ca lcium-dependent …

The memory of fear extinction is context dependent: fear that is suppressed in one context
readily renews in another. Understanding of the underlying neuronal circuits is, therefore, of …

Group 1 metabotropic glutamate receptor (mGluR)-stimulated protein synthesis and long-
term synaptic depression (mGluR-LTD) are altered in the mouse model of fragile X …

Experience-induced expression of immediate-early gene Arc (also known as Arg3. 1) is
known to be important for consolidation of memory. Using in vivo longitudinal multiphoton …

Protein synthesis is highly regulated throughout nervous system development, plasticity and
regeneration. However, tracking the distributions of specific new protein species has not …

Because living systems depend on their environment, the evolution of environmental
adaptability is inseparable from the evolution of life itself (Pross 2003). In animals and …

Memories are stored within neuronal ensembles in the brain. Modern genetic techniques
can be used to not only visualize specific neuronal ensembles that encode memories (eg …