Understanding the functional effects of the wide-range of aberrant genetic characteristics
associated with the human chromosome 8q24 region in cancer remains daunting due to the …

Wnt/β‐catenin signalling is known to play many roles in metazoan development and tissue
homeostasis. Misregulation of the pathway has also been linked to many human diseases …

BACKGROUND: A high circulating concentration of interleukin 6 is associated with
increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a …

Pooling genome-wide association studies (GWASs) increases power but also poses
methodological challenges because studies are often heterogeneous. For example …

In Western countries, prostate cancer is the most prevalent cancer of men and one of the
leading causes of cancer-related death in men. Several genome-wide association studies …

Colorectal cancer is the second leading cause of cancer death in developed countries.
Genome-wide association studies (GWAS) have successfully identified novel susceptibility …

Genome-wide association studies (GWAS) have identified more than a dozen loci
associated with colorectal cancer (CRC) risk. Here, we examined potential effect …

Risk prediction models are important to identify individuals at high risk of developing the
disease who can then be offered individually tailored clinical management, targeted …

Five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have
been reported: rs2910164 (5q24); rs6983267 (8q24); rs965513 and rs1867277 (9q22); and …

Background Colorectal cancer is a major global public health problem, with approximately
950 000 patients newly diagnosed each year. We report the first comprehensive field …