Bone erosion is a central feature of rheumatoid arthritis and is associated with disease
severity and poor functional outcome. Erosion of periarticular cortical bone, the typical …

OBJECTIVES: To review the current literature on the regulation of bone remodelling at the
cellular level. DESIGN AND METHODS: The cellular activities of the cells in the basic …

Autoimmunity is complicated by bone loss. In human rheumatoid arthritis (RA), the most
severe inflammatory joint disease, autoantibodies against citrullinated proteins are among …

The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and
bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone …

Bone is continuously renewed through a dynamic balance between bone resorption and
formation. This process is the fundamental basis for the maintenance of normal bone mass …

The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway mediates
multiple adaptive T-cell functions, but recent studies have shown that calcineurin/NFAT …

Investigations into interactions between the skeletal and immune systems were developed
during research into arthritis, with characterization of T-cell-mediated regulation of …

Eur J Clin Invest 2012; 42 (12): 1332–1341 Abstract Background Bone remodelling
maintains skeletal integrity by osteoclasts removing foci of damaged bone and osteoblasts …

Inflammation plays vital roles in protective responses against pathogens and tissue repair,
however, improper resolution of inflammatory networks is centrally involved in the …

Tumor necrosis factor (TNF) plays a key role in the pathogenesis of inflammatory bone
resorption and associated morbidity in diseases such as rheumatoid arthritis and …