Converging translational evidence has implicated elevated immune-inflammatory signaling
activity in the pathoetiology of mood disorders, including major depressive disorder and …

Increasing evidence suggests that inflammation responses play an important role in the
pathophysiology of depression. Clinically depressed patients manifest higher levels of …

Background: Lower concentrations of n− 3 PUFAs have been reported to be associated with
cognitive impairment and dementia, but also with depression—itself a potential risk factor for …

The polyunsaturated fatty acids (PUFAs), arachidonic acid (AA, 20: 4n− 6) and
docosahexaenoic acid (DHA, 22: 6n− 3), important second messengers in brain, are …

BACKGROUNDS: Depression in late life often follows a chronic course with residual
depressive and anxiety symptoms. Levels of omega-3 polyunsaturated fatty acids (PUFAs) …

Psychiatric patients frequently exhibit long-chain n− 3 (LCn− 3) fatty acid deficits and
elevated triglyceride (TAG) production following chronic exposure to second generation …

Bipolar disorder (previously also labeled manic-depressive illness) is typically referred to as
an episodic, yet lifelong and clinically severe affective (or mood) disorder, affecting …

A compound having the formula (I) R1-COOH wherein R1 is an alkyl or alkenyl group having
a C 7-11 backbone, optionally branched with a C 1-6 alkyl group at any C position in the …

As noted in Chapter 6, there is evidence suggesting that the prevalence of Bipolar II disorder
(BP II) is increasing. Any suggested increase could be artefactual, reflecting changes in …