The emerging paradigm of network medicine in the study of human disease
SY Chan, J Loscalzo - Circulation research, 2012 - Am Heart Assoc
The molecular pathways that govern human disease consist of molecular circuits that
coalesce into complex, overlapping networks. These network pathways are presumably …
coalesce into complex, overlapping networks. These network pathways are presumably …
DIANA miRPath v. 2.0: investigating the combinatorial effect of microRNAs in pathways
MicroRNAs (miRNAs) are key regulators of diverse biological processes and their functional
analysis has been deemed central in many research pipelines. The new version of DIANA …
analysis has been deemed central in many research pipelines. The new version of DIANA …
[HTML][HTML] BRCA1 and its network of interacting partners
CM Christou, K Kyriacou - Biology, 2012 - mdpi.com
BRCA1 is a large multi-domain protein with a pivotal role in maintaining genome stability
and cell cycle progression. Germline mutations in the BRCA1 gene confer an estimated …
and cell cycle progression. Germline mutations in the BRCA1 gene confer an estimated …
MiRGator v3. 0: a microRNA portal for deep sequencing, expression profiling and mRNA targeting
Biogenesis and molecular function are two key subjects in the field of microRNA (miRNA)
research. Deep sequencing has become the principal technique in cataloging of miRNA …
research. Deep sequencing has become the principal technique in cataloging of miRNA …
MAGIA2: from miRNA and genes expression data integrative analysis to microRNA–transcription factor mixed regulatory circuits (2012 update)
Abstract MAGIA2 (http://gencomp. bio. unipd. it/magia2) is an update, extension and
evolution of the MAGIA web tool. It is dedicated to the integrated analysis of in silico target …
evolution of the MAGIA web tool. It is dedicated to the integrated analysis of in silico target …
[HTML][HTML] Bioinformatics analysis of microRNA and putative target genes in bovine mammary tissue infected with Streptococcus uberis
MicroRNA (miRNA) are small single-stranded noncoding RNA with important roles in
regulating innate immunity in nonruminants via transcriptional and posttranscriptional …
regulating innate immunity in nonruminants via transcriptional and posttranscriptional …
[HTML][HTML] Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts
H Hu, Y Zhang, XH Cai, JF Huang… - Oncology …, 2012 - spandidos-publications.com
Osteosarcoma (OS) is the most common primary malignant bone tumor, particularly in
adolescents and young adults. Early diagnosis remains a significant problem in the clinical …
adolescents and young adults. Early diagnosis remains a significant problem in the clinical …
Respiratory syncytial virus regulates human microRNAs by using mechanisms involving beta interferon and NF-κB
NJ Thornburg, SL Hayward, JE Crowe Jr - MBio, 2012 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is the most common viral cause of severe lower respiratory
tract illness in infants and children. The virus replicates in polarized epithelial cells in the …
tract illness in infants and children. The virus replicates in polarized epithelial cells in the …
One decade of development and evolution of microRNA target prediction algorithms
PH Reyes∼ Herrera, E Ficarra - Genomics, Proteomics and …, 2012 - academic.oup.com
Nearly two decades have passed since the publication of the first study reporting the
discovery of microRNAs (miRNAs). The key role of miRNAs in post-transcriptional gene …
discovery of microRNAs (miRNAs). The key role of miRNAs in post-transcriptional gene …
[HTML][HTML] miR-203 regulates cell proliferation through its influence on Hakai expression
V Abella, M Valladares, T Rodriguez, M Haz, M Blanco… - PloS one, 2012 - journals.plos.org
Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we
present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 …
present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 …