Pharmacogenomics of opioids and perioperative pain management

S Sadhasivam, V Chidambaran - Pharmacogenomics, 2012 - Future Medicine
Inadequate pain relief and adverse effects from analgesics remain common in children and
adults during the perioperative period. Opioids are the most commonly used analgesics in …

[HTML][HTML] Population prevalence of high dose paracetamol in dispensed paracetamol/opioid prescription combinations: an observational study

R Clark, JE Fisher, IS Sketris, GM Johnston - BMC clinical pharmacology, 2012 - Springer
Background Paracetamol (acetaminophen) is generally considered a safe medication, but is
associated with hepatotoxicity at doses above doses of 4.0 g/day, and even below this daily …

Is there a role for therapeutic drug monitoring with codeine?

LE Kelly, P Madadi - Therapeutic drug monitoring, 2012 - journals.lww.com
Codeine is an old and commonly used analgesic agent for mild to moderate pain. It is the
prototypical “prodrug” in that its analgesic effect is almost wholly dependent on its …

Apnea and oxygen desaturations in children treated with opioids after adenotonsillectomy for obstructive sleep apnea syndrome: a prospective pilot study

JD Khetani, P Madadi, DD Sommer, D Reddy… - Pediatric Drugs, 2012 - Springer
Background: Recent case reports have alerted the medical community of fatality in children
receiving codeine after tonsillectomy and/or adenoidectomy for obstructive sleep apnea …

Preventing opioid-related deaths in children undergoing surgery

S Sadhasivam, CM Myer III - Pain Medicine, 2012 - academic.oup.com
Tonsillectomy is one of the most commonly done surgical procedures in children. There are
many unreported deaths following tonsillectomy in children due to opioids. Genetic …

Pain management in children: Part 2—A transition from codeine to morphine for moderate to severe pain in children

C Wong, E Lau, L Palozzi… - … Journal/Revue des …, 2012 - journals.sagepub.com
Opioids remain the agent of choice for the treatment of moderate to severe pain in both
adults and children. Codeine, an opioid analogue, is commonly used in the treatment of mild …

Opioid-induced sleep apnea: is it a real problem?

WJ Randerath, S George - Journal of Clinical Sleep Medicine, 2012 - jcsm.aasm.org
American Pain Society stated that “it is now accepted… that respiratory depression induced
by opioids tends to be a short lived phenomenon, generally occurs only in opioid-naïve …

Pediatric acute and surgical pain management: recent advances and future perspectives

V Chidambaran, S Sadhasivam - International anesthesiology …, 2012 - journals.lww.com
Pediatric Acute and Surgical Pain Management: Recent Advance... : International
Anesthesiology Clinics Pediatric Acute and Surgical Pain Management: Recent Advances and …

New ways to detect adverse drug reactions in pediatrics

M Rieder - Pediatric Clinics, 2012 - pediatric.theclinics.com
For most of recorded history, medical treatment was conducted using therapies that would
today be considered complementary or alternative medicine. 1 Medications were typically …

[PDF][PDF] 哌拉西林钠他唑巴坦钠致抽搐

郭珩, 辛华雯, 逄玉涛, 范星 - 药物不良反应杂志, 2012 - cadrj.com
入院后给予COPD常规治疗,疾培养及药敏试验结 Page 1 ·324· 药物不良反应杂志2012年10月第
14卷第5期 4DRJ,October2O72,Vol 4. Wo.5 讨论本例患者无精神病史和家族史,也无药 物过敏史 …