Cancers are complex multifactorial diseases. For centuries, conventional organ-based
classification system (ie, breast cancer, lung cancer, colon cancer, colorectal cancer …

In recent years, attention has focused on the biology and potential clinical importance of the
CpG island methylator phenotype (CIMP) in colorectal cancer (CRC). While it is generally …

Objective Colorectal cancer is typically classified into proximal colon, distal colon and rectal
cancer. Tumour genetic and epigenetic features differ by tumour location. Considering a …

Purpose: Alterations in the RAS-RAF-MAP2K (MEK)-MAPK signaling pathway are major
drivers in colorectal carcinogenesis. In colorectal cancer, BRAF mutation is associated with …

In the 1980s, epidemiological and molecular data suggested that cancers arising at different
subsites may be biologically disparate, implying different cancer aetiologies or evolutions …

Epidemiological evidence continues to accumulate on the benefits of physical activity in
relation to cancer risk, progression and mortality. Recent studies suggest that sedentary …

The role of longitudinal cohort studies in epigenetic epidemiology: challenges and
opportunities | Genome Biology Skip to main content SpringerLink Account Menu Find a journal …

Background How body size influences risk of molecular subtypes of colorectal cancer (CRC)
is unclear. We investigated whether measures of anthropometry differentially influence risk …

In recent decades, epidemiology, public health, and medical sciences have been
increasingly compartmentalized into narrower disciplines. The authors recognize the value …

Abstract Purpose: African American colorectal cancer patients have worse survival
outcomes than Caucasian patients. To determine whether differences exist in the molecular …