Regulation of nonsense‐mediated mRNA decay
L Huang, MF Wilkinson - Wiley Interdisciplinary Reviews: RNA, 2012 - Wiley Online Library
Nonsense‐mediated mRNA decay (NMD) is a highly conserved pathway that was originally
identified as a RNA surveillance mechanism that degrades aberrant mRNAs harboring …
identified as a RNA surveillance mechanism that degrades aberrant mRNAs harboring …
CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex
J Saulière, V Murigneux, Z Wang… - Nature structural & …, 2012 - nature.com
The exon junction complex (EJC) is a central effector of the fate of mRNAs, linking nuclear
processing to mRNA transport, translation and surveillance. However, little is known about …
processing to mRNA transport, translation and surveillance. However, little is known about …
Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability
UPF1 eliminates aberrant mRNAs harboring premature termination codons, and regulates
the steady-state levels of normal physiological mRNAs. Although genome-wide studies of …
the steady-state levels of normal physiological mRNAs. Although genome-wide studies of …
The mechanism of the second step of pre‐mRNA splicing
DS Horowitz - Wiley Interdisciplinary Reviews: RNA, 2012 - Wiley Online Library
The molecular mechanisms of the second step of pre‐mRNA splicing in yeast and higher
eukaryotes are reviewed. The important elements in the pre‐mRNA, the participating …
eukaryotes are reviewed. The important elements in the pre‐mRNA, the participating …
Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators
L Michelle, A Cloutier, J Toutant, L Shkreta… - … and cellular biology, 2012 - Taylor & Francis
Several apoptotic regulators, including Bcl-x, are alternatively spliced to produce isoforms
with opposite functions. We have used an RNA interference strategy to map the regulatory …
with opposite functions. We have used an RNA interference strategy to map the regulatory …
[HTML][HTML] CWC22 connects pre-mRNA splicing and exon junction complex assembly
AL Steckelberg, V Boehm, AM Gromadzka, NH Gehring - Cell reports, 2012 - cell.com
The exon junction complex (EJC) is a key regulator of posttranscriptional mRNA fate and
binds to mRNA during splicing. Although the composition of EJCs is well understood, the …
binds to mRNA during splicing. Although the composition of EJCs is well understood, the …
Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly
I Barbosa, N Haque, F Fiorini, C Barrandon… - Nature structural & …, 2012 - nature.com
The exon-junction complex (EJC) functionally links splicing to subsequent mRNA
localization, translation and stability. Sequence-independent binding of the EJC core to RNA …
localization, translation and stability. Sequence-independent binding of the EJC core to RNA …
Perispeckles are major assembly sites for the exon junction core complex
E Daguenet, A Baguet, S Degot… - Molecular Biology of …, 2012 - Am Soc Cell Biol
The exon junction complex (EJC) is loaded onto mRNAs as a consequence of splicing and
regulates multiple posttranscriptional events. MLN51, Magoh, Y14, and eIF4A3 form a highly …
regulates multiple posttranscriptional events. MLN51, Magoh, Y14, and eIF4A3 form a highly …
[HTML][HTML] Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay
MJ Ochs, BL Sorg, L Pufahl, M Grez, B Suess… - PLoS …, 2012 - journals.plos.org
5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes
(LT), a group of inflammatory lipid mediators derived from arachidonic acid. Here, we …
(LT), a group of inflammatory lipid mediators derived from arachidonic acid. Here, we …
无义介导的mRNA 降解机制及其在单基因遗传病中的作用
郭文婷， 徐汪洋， 顾鸣敏 - 遗传, 2012 - chinagene.cn
无义介导的mRNA 降解(Nonsense-mediated mRNA decay, NMD) 是一种广泛存在于真核生物
细胞中的mRNA 质量监控机制. 该机制通过识别和降解含有提前终止密码子(Premature …
细胞中的mRNA 质量监控机制. 该机制通过识别和降解含有提前终止密码子(Premature …