What is the prognosis for new centrally-acting anti-obesity drugs?

DJ Heal, J Gosden, SL Smith - Neuropharmacology, 2012 - Elsevier
Obesity is a global problem that is predominantly caused by the increasing adoption of a low-
cost, Westernised diet that is rich in fat and sugar and a more sedentary lifestyle. The costs …

Vilsmeier-Type Reaction of Dimethylaminoalkenoyl Cyclopropanes: One-Pot Access to 2,3-Dihydrofuro [3,2-c]pyridin-4(5H)-ones

P Huang, N Zhang, R Zhang, D Dong - Organic letters, 2012 - ACS Publications
A domino reaction of readily available 1-carbamoyl-1-dimethylaminoalkenoylcyclopropanes
in the presence of triflic anhydride (Tf2O) in N, N-dimethylformamide (DMF) is described …

Multi-component anion relay cascade of 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile: access to biscyanoethylated furo [3, 2-c] pyridinones

S Lin, Y Wei, F Liang, B Zhao, Y Liu… - Organic & Biomolecular …, 2012 - pubs.rsc.org
A highly efficient multi-component anion relay cascade reaction based on 1-
acetylcyclopropanecarboxamides, aldehydes and acrylonitrile has been developed, which …

Neuropeptide receptors: Novel therapeutic targets for depression and anxiety disorders

S Chaki, K Kanuma - 2012 - books.rsc.org
Stress has been well recognized as the primary cause of depression and anxiety disorders.
In the brain, short-chain neurotransmitters or neuromodulators, called neuropeptides, have …

The Pathophysiology of Schizophrenia

A Szegedi, M Egan - 2012 - books.rsc.org
Schizophrenia as currently conceptualized in the current version of the Diagnostic and
Statistical Manual of Mental Disorders (DSM-IV-TR) constitutes a broad and heterogeneous …