Data mining of available biomedical data and information has greatly boosted target
discovery in the 'omics' era. Target discovery is the key step in the biomarker and drug …

BACKGROUND Prostate cancer is the most common cancer diagnosis in men and a leading
cause of death. Improvements in disease management would have a significant impact and …

Background Hepatoblastoma (HB) is an embryonal liver neoplasm of early childhood with a
poor prognosis for patients with distant metastases and vascular invasion. We and others …

MicroRNAs (miRNAs) are an abundant class of noncoding RNAs that function to regulate
post-transcriptional gene expression, predominantly by translational repression. In addition …

Gemcitabine is indicated in combination with cisplatin as first-line therapy for solid tumours
including non-small cell lung cancer (NSCLC), bladder cancer and mesothelioma …

Purpose: IGFBP7 belongs to a family of insulin-like growth factor-1 regulatory binding
proteins. IGFBP7 hypermethylation is associated with its down-regulation in various …

OBJECTIVE:: The efficacy of docetaxel has recently been shown to be increased under
hypoxic conditions through the down-regulation of hypoxia-inducible-factor 1α (HIF1A) …

Aberrant DNA methylation in gene promoters causes gene silencing and is a common event
in prostate cancer development and progression. While commonly identified methylated …