Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis,,.
We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …

Alteration of the acetylation state of histone proteins contributes to transcriptional regulation
and epigenetic inheritance. Dysregulation of these processes may lead to human diseases …

The individual risk for common diseases not only depends on genetic but also on epigenetic
polymorphisms. To assess the role of epigenetic variations in the individual risk for obesity …

Protein lysine acetyltransferases (HATs or PATs) acetylate histones and other proteins, and
are principally modeled as transcriptional coactivators. CREB binding protein (CBP …

Genetic and environmental factors play a role in the development of alcoholism. Whole-
genome expression profiling has highlighted the importance of several genes that may …

The molecular mechanisms linking glucose metabolism with active transcription remain
undercharacterized in mammalian cells. Using nuclear factor-κB (NF-κB) as a glucose …

Melatonin is an indoleamine secreted by the pineal gland as well as a plant‐derived product
that exerts potential anti‐inflammatory properties, but the mechanisms of action remain …

Protein acetylation is an important posttranslational modification with the recent identification
of new substrates and enzymes, new links to disease, and modulators of protein acetylation …

In this review article we present a general overview of the recent progress in the newly
developing area of the study of protein-ligand interaction by surface enhanced Raman …