Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …

Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …

Small RNA-mediated gene regulation during development causes long-lasting changes in
cellular phenotypes. To determine whether small RNAs of the adult brain can regulate …

Prion diseases are transmissible neurodegenerative disorders affecting both humans and
animals. The cellular prion protein, PrP C, and the abnormal infectious form, PrP Sc, are …

The development of deep sequencing has enabled the identification of novel microRNAs
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …

Background Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of
sporadic and familial Parkinson's disease (PD) as well as dementia with Lewy bodies, with …

We introduce two large-scale resources for functional analysis of microRNA (miRNA): a
decoy library for inhibiting miRNA function and a sensor library for monitoring microRNA …

The transition from ductal carcinoma in situ to invasive ductal carcinoma is a key event in
breast cancer progression that is still not well understood. To discover the microRNAs …

The largest gene cluster of human microRNAs (miRNAs), the chromosome 19 miRNA
cluster (C19MC), is exclusively expressed in the placenta and in undifferentiated cells. The …

We present the first genomic-scale analysis addressing the phylogenetic position of turtles,
using over 1000 loci from representatives of all major reptile lineages including tuatara …