Bacteria and archaea possess adaptive immune systems that rely on small RNAs for
defense against invasive genetic elements. CRISPR (c lustered r egularly i nterspaced s hort …

Besides their commonly attributed role in the maintenance of low-copy number plasmids,
toxin/antitoxin (TA) loci, also called 'addiction modules', have been found in chromosomes …

Background Protein-DNA interactions are important for many cellular processes, however
structural knowledge for a large fraction of known and putative complexes is still lacking …

Self-assembly of ordered water tetramers in an encapsulated [Br(H 2 O) 12 ] − complex -
Chemical Communications (RSC Publishing) DOI:10.1039/C2CC30767G Royal Society of …

Protein-DNA binding plays a key role in both gene regulation–through highly specific
transcription factor-DNA interactions–and in chromatin organization, through the largely non …

This chapter summarises empirical information on the structure of water molecules bound to
proteins. The focus is on structures solved by X-ray crystallography, although …

The proline-rich homeodomain (PRH)–DNA complex consists of a protein with 60 residues
and a 13-base-pair DNA. The PRH protein is a transcription factor that plays a key role in the …

Protein dimers and multimers are often employed by nature for DNA and RNA handling and
formation of specific, high-affinity protein-oligonucleotide complexes. The repeating structure …

The central role of RNA in numerous biological processes including translation, 1 protein
localization, 2 gene regulation, 3 RNA processing, 4 and viral replication5 calls for a …

Since their discovery in the nineteen-seventies, a collection of simple enzymes termed Type
II restriction endonucleases, made by microbes to ward off viral infections, have transformed …