Engineering microscale topographies to control the cell–substrate interface

M Nikkhah, F Edalat, S Manoucheri, A Khademhosseini - Biomaterials, 2012 - Elsevier
Cells in their in vivo microenvironment constantly encounter and respond to a multitude of
signals. While the role of biochemical signals has long been appreciated, the importance of …

Review Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices

F Vollmer, L Yang - Nanophotonics, 2012 - degruyter.com
Optical microcavities that confine light in high-Q resonance promise all of the capabilities
required for a successful next-generation microsystem biodetection technology. Label-free …

Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography

R Gauvin, YC Chen, JW Lee, P Soman, P Zorlutuna… - Biomaterials, 2012 - Elsevier
The success of tissue engineering will rely on the ability to generate complex, cell seeded
three-dimensional (3D) structures. Therefore, methods that can be used to precisely …

Advances in the formation, use and understanding of multi-cellular spheroids

TM Achilli, J Meyer, JR Morgan - Expert opinion on biological …, 2012 - Taylor & Francis
Introduction: Developing in vitro models for studying cell biology and cell physiology is of
great importance to the fields of biotechnology, cancer research, drug discovery, toxicity …

Synthesis, properties and biomedical applications of poly (glycerol sebacate)(PGS): A review

R Rai, M Tallawi, A Grigore, AR Boccaccini - Progress in polymer science, 2012 - Elsevier
Poly (glycerol sebacate)(PGS) is a biodegradable polymer increasingly used in a variety of
biomedical applications. This polyester is prepared by polycondensation of glycerol and …

Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials

E Pedraza, MM Coronel, CA Fraker… - Proceedings of the …, 2012 - National Acad Sciences
A major hindrance in engineering tissues containing highly metabolically active cells is the
insufficient oxygenation of these implants, which results in dying or dysfunctional cells in …

Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering

BG Chung, KH Lee, A Khademhosseini, SH Lee - Lab on a Chip, 2012 - pubs.rsc.org
Microfluidic technologies are emerging as an enabling tool for various applications in tissue
engineering and cell biology. One emerging use of microfluidic systems is the generation of …

[HTML][HTML] Rapid fabrication of complex 3D extracellular microenvironments by dynamic optical projection stereolithography

AP Zhang, X Qu, P Soman, KC Hribar… - … (Deerfield Beach, Fla …, 2012 - ncbi.nlm.nih.gov
Cells can sense surface topography of the surround extracellular matrix (ECM) and can
respond to these physical cues by altering their alignment and migration.[1, 2] Furthermore …

The mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules

H Shin, BD Olsen, A Khademhosseini - Biomaterials, 2012 - Elsevier
A major goal in the application of hydrogels for tissue engineering scaffolds, especially for
load-bearing tissues such as cartilage, is to develop hydrogels with high mechanical …

Microfabricated biomaterials for engineering 3D tissues

P Zorlutuna, N Annabi, G Camci‐Unal… - Advanced …, 2012 - Wiley Online Library
Mimicking natural tissue structure is crucial for engineered tissues with intended
applications ranging from regenerative medicine to biorobotics. Native tissues are highly …