Aging, atherosclerosis, and IGF-1

Y Higashi, S Sukhanov, A Anwar… - … Series A: Biomedical …, 2012 - academic.oup.com
Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that
circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major …

Selected physiological effects of ultrafine particles in acute cardiovascular morbidity

S Weichenthal - Environmental Research, 2012 - Elsevier
Ultrafine particles (UFPs) have emerged as a potentially important environmental health
concern as they are produced in large numbers by vehicle emissions and may contribute to …

[HTML][HTML] The dipeptidyl peptidase-4 inhibitor sitagliptin improves vascular endothelial function in type 2 diabetes

Y Kubota, M Miyamoto, G Takagi, T Ikeda… - Journal of Korean …, 2012 - ncbi.nlm.nih.gov
The vascular endothelial function is impaired in the very early stage of atherosclerosis in
diabetic patients. The goal of this study was to identify the mechanism underlying the …

Dysfunction of endothelial progenitor cells under diabetic conditions and its underlying mechanisms

KA Kim, YJ Shin, JH Kim, H Lee, SY Noh… - Archives of pharmacal …, 2012 - Springer
Cardiovascular complications have been major concerns in the treatment of diabetes, and
up to 80% of all deaths in diabetic patients are linked to cardiovascular problems. Impaired …

Cardiovascular mortality in psoriasis and psoriatic arthritis: epidemiology, pathomechanisms, therapeutic implications, and perspectives

WH Boehncke, S Boehncke - Current rheumatology reports, 2012 - Springer
Psoriasis and psoriatic arthritis are associated with an increased cardiovascular mortality.
Although the underlying pathogenesis is not yet fully understood, it is clear that these …

Endothelial and platelet function alterations in HIV-infected patients

P Gresele, E Falcinelli, M Sebastiano, F Baldelli - Thrombosis research, 2012 - Elsevier
The HIV epidemic has huge dimensions: in 2009, 33.3 million people worldwide, including
2.5 million children, were affected by human immunodeficiency virus (HIV) infection. The …

[HTML][HTML] Sympathetic overactivity and cardiovascular disease in patients with chronic obstructive pulmonary disease (COPD)

AJR van Gestel, M Kohler… - Discovery …, 2012 - discoverymedicine.com
Cardiovascular disease plays an important role regarding the morbidity and mortality in
patients with chronic obstructive pulmonary disease (COPD). Sympathetic overactivity has …

[HTML][HTML] OSA and atherosclerosis

MMS Lui, M Sau-Man - Journal of Thoracic Disease, 2012 - ncbi.nlm.nih.gov
Untreated obstructive sleep apnea (OSA) is increasingly recognized as a risk factor
contributing to cardiovascular morbidity and mortality. Research in recent decades has …

Cardiovascular Benefits of GLP‐1‐BasedTherapies in Patients with Diabetes Mellitus Type 2: Effects on Endothelial and Vascular Dysfunction beyond Glycemic …

T Forst, MM Weber, A Pfützner - Journal of Diabetes Research, 2012 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is a progressive multisystemic disease accompanied by
vascular dysfunction and a tremendous increase in cardiovascular mortality. Numerous …

Fluoxetine effect on aortic nitric oxide-dependent vasorelaxation in the unpredictable chronic mild stress model of depression in mice

E Isingrini, C Belzung, JL Freslon… - Psychosomatic …, 2012 - journals.lww.com
Objective Major depression is an independent risk factor for the development of
cardiovascular diseases. However, the exact mechanism by which depression may induce …