Low-grade inflammation is a common feature in subjects with type 2 diabetes (T2D). Heart
disease, the metabolic syndrome and T2D all have in common the increased concentration …

Because of their rare detection in atherosclerotic lesions, the involvement of neutrophils in
the pathophysiology of atherosclerosis has been largely denied. However, over the past …

Chronic inflammation is the basis of various chronic illnesses including cancer and vascular
diseases. However, much has yet to be learned how inflammation becomes chronic …

Fetal hypoxia is a common complication of pregnancy. It has been shown to programme
cardiac and endothelial dysfunction in the offspring in adult life. However, the mechanisms …

Sound data support the concept that in atherosclerosis, inflammation and dyslipidemia
intersect each other and that irrespective of the initiator, both participate from the early …

Background—Molecular imaging is a fast emerging technology allowing noninvasive
detection of vascular pathologies. However, imaging modalities offering high resolution …

Background Mice deficient in the LDL receptor (Ldlr−/− mice) have been widely used as a
model to mimic human atherosclerosis. However, the time-course of atherosclerotic lesion …

Monocyte-derived macrophages play a key role in atherogenesis because their
transformation into foam cells is responsible for deposition of lipids in plaques within arterial …

Oxidized low density lipoprotein (ox-LDL), a risk factor of atherosclerosis, facilitates the
formation and vulnerability of atherosclerotic plaque, thus contributing to several clinical …

Angiotensin II (Ang II) promotes vascular disease through several mechanisms including by
producing oxidative stress and endothelial dysfunction. Although multiple potential sources …