TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
FG Rücker, RF Schlenk, L Bullinger… - Blood, The Journal …, 2012 - ashpublications.org
To assess the frequency of TP53 alterations and their correlation with other genetic changes
and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed …
and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed …
Acute myeloid leukemia in older adults
Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median
age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from …
age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from …
Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies
S Kayser, M Zucknick, K Doehner… - Blood, The Journal …, 2012 - ashpublications.org
We aimed to determine the prognostic impact of monosomal karyotype (MK) in acute
myeloid leukemia (AML) in the context of the current World Health Organization (WHO) …
myeloid leukemia (AML) in the context of the current World Health Organization (WHO) …
Mutated regions of nucleophosmin 1 elicit both CD4+ and CD8+ T-cell responses in patients with acute myeloid leukemia
J Greiner, Y Ono, S Hofmann, A Schmitt… - Blood, The Journal …, 2012 - ashpublications.org
Mutations in the nucleophosmin gene (NPM1 mut) are one of the most frequent molecular
alterations in acute myeloid leukemia (AML), and immune responses may contribute to the …
alterations in acute myeloid leukemia (AML), and immune responses may contribute to the …
Prognostic implications of genetic aberrations in acute myelogenous leukemia with normal cytogenetics
H Ghanem, N Tank, IA Tabbara - American journal of …, 2012 - Wiley Online Library
Acute myelogenous leukemia (AML) is a genetically heterogeneous disease in which
somatic mutations, that disturb cellular growth, proliferation, and differentiation, accumulate …
somatic mutations, that disturb cellular growth, proliferation, and differentiation, accumulate …
[PDF][PDF] Inzidenz und prognostische Bedeutung von Mutationen des Nucleophosmin (NPM1) Gens bei der akuten myeloischen Leukämie (AML) des älteren Patienten …
BP Krebs - 2012 - oparu.uni-ulm.de
Hauptziele der Arbeit waren: 1. Die Inzidenz von NPM1 Mutationen an einer großen Kohorte
(AML HD98-B Studie und AMLSG 06-04 Studie) älterer AML Patienten (> 60 Jahre) …
(AML HD98-B Studie und AMLSG 06-04 Studie) älterer AML Patienten (> 60 Jahre) …