To understand how complicated pain assessment in neonates and young infants is, this
article presents 3 scenarios: a 25-week-old neonate with sepsis in the neonatal intensive …

Although the principles of drug disposition also apply in neonates, their specific
characteristics warrant focussed assessment. Children display maturation in drug …

Abstract Background and Objectives: The wide variability in pharmacokinetics of busulfan in
children is one factor influencing outcomes such as toxicity and event-free survival. A meta …

Purpose To explore different allometric equations for scaling clearance across the human
life-span using propofol as a model drug. Methods Data from seven previously published …

Background Intravenous (IV) busulfan (Bu) dosing approved in Europe based on 5 body
weight (BW) strata has been validated for targeting Bu exposures in children undergoing …

Substantial variation exists in response to standard doses of codeine ranging from poor
analgesia to life‐threatening central nervous system (CNS) depression. We aimed to …

Background: Morphine is widely used throughout the human life span. Several
pharmacokinetic models have been proposed to predict how morphine clearance changes …

Dose selection for “first in children” trials often relies on scaling of the pharmacokinetics from
adults to children. Commonly used approaches are physiologically-based pharmacokinetic …

The onset and maturation, or so-called ontogeny, of hepatic glucuronidation is important for
the clearance of a number of drugs in children. The current review discusses methods for …

Background: In children, a large variability in pharmacokinetics of midazolam, a cytochrome
P450 3A4/5 (CYP3A4/5) enzyme substrate, has been described, which cannot be explained …