Synapses and dendritic spines as pathogenic targets in Alzheimer's disease
Synapses are sites of cell‐cell contacts that transmit electrical or chemical signals in the
brain. Dendritic spines are protrusions on dendritic shaft where excitatory synapses are …
brain. Dendritic spines are protrusions on dendritic shaft where excitatory synapses are …
[HTML][HTML] Tau promotes neurodegeneration via DRP1 mislocalization in vivo
B DuBoff, J Götz, MB Feany - Neuron, 2012 - cell.com
Mitochondrial abnormalities have been documented in Alzheimer's disease and related
neurodegenerative disorders, but the causal relationship between mitochondrial changes …
neurodegenerative disorders, but the causal relationship between mitochondrial changes …
Drosophila Models of Tauopathies: What Have We Learned?
M Gistelinck, JC Lambert, P Callaerts… - International Journal …, 2012 - Wiley Online Library
Aggregates of the microtubule‐associated protein Tau are neuropathological hallmark
lesions in Alzheimer′ s disease (AD) and related primary tauopathies. In addition, Tau is …
lesions in Alzheimer′ s disease (AD) and related primary tauopathies. In addition, Tau is …
High dimensional endophenotype ranking in the search for major depression risk genes
BACKGROUND: Despite overwhelming evidence that major depression is highly heritable,
recent studies have localized only a single depression-related locus reaching genome-wide …
recent studies have localized only a single depression-related locus reaching genome-wide …
[HTML][HTML] Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease–related tau phosphorylation via PAR-1
K Iijima-Ando, M Sekiya, A Maruko-Otake, Y Ohtake… - 2012 - journals.plos.org
Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved
in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions …
in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions …
NMNAT suppresses Tau-induced neurodegeneration by promoting clearance of hyperphosphorylated Tau oligomers in a Drosophila model of tauopathy
YO Ali, K Ruan, RG Zhai - Human molecular genetics, 2012 - academic.oup.com
Tauopathies, including Alzheimer's disease, are a group of neurodegenerative diseases
characterized by abnormal tau hyperphosphorylation that leads to formation of …
characterized by abnormal tau hyperphosphorylation that leads to formation of …
A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading
cause of dementia in the elderly. Accumulating evidence supports soluble amyloid-β (Aβ) …
cause of dementia in the elderly. Accumulating evidence supports soluble amyloid-β (Aβ) …
Phosphorylation of microtubule‐associated protein tau by AMPK‐related kinases
H Yoshida, M Goedert - Journal of neurochemistry, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 165–176. Abstract Microtubule‐associated protein tau is
abnormally hyperphosphorylated in the intracellular filamentous inclusions seen in …
abnormally hyperphosphorylated in the intracellular filamentous inclusions seen in …
Drosophila models of proteinopathies: the little fly that could
DE Rincon-Limas, K Jensen… - Current …, 2012 - ingentaconnect.com
Alzheimer's, Parkinson's, and Huntington's disease are complex neurodegenerative
conditions with high prevalence character-ized by protein misfolding and deposition in the …
conditions with high prevalence character-ized by protein misfolding and deposition in the …
What is the pathological significance of tau oligomers?
CM Cowan, S Quraishe, A Mudher - Biochemical Society …, 2012 - portlandpress.com
Insoluble aggregates of the microtubule-associated protein tau characterize a number of
neurodegenerative diseases collectively termed tauopathies. These aggregates comprise …
neurodegenerative diseases collectively termed tauopathies. These aggregates comprise …