Synapses are sites of cell‐cell contacts that transmit electrical or chemical signals in the
brain. Dendritic spines are protrusions on dendritic shaft where excitatory synapses are …

Mitochondrial abnormalities have been documented in Alzheimer's disease and related
neurodegenerative disorders, but the causal relationship between mitochondrial changes …

Aggregates of the microtubule‐associated protein Tau are neuropathological hallmark
lesions in Alzheimer′ s disease (AD) and related primary tauopathies. In addition, Tau is …

BACKGROUND: Despite overwhelming evidence that major depression is highly heritable,
recent studies have localized only a single depression-related locus reaching genome-wide …

Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved
in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions …

Tauopathies, including Alzheimer's disease, are a group of neurodegenerative diseases
characterized by abnormal tau hyperphosphorylation that leads to formation of …

Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading
cause of dementia in the elderly. Accumulating evidence supports soluble amyloid-β (Aβ) …

J. Neurochem.(2012) 120, 165–176. Abstract Microtubule‐associated protein tau is
abnormally hyperphosphorylated in the intracellular filamentous inclusions seen in …

Alzheimer's, Parkinson's, and Huntington's disease are complex neurodegenerative
conditions with high prevalence character-ized by protein misfolding and deposition in the …

Insoluble aggregates of the microtubule-associated protein tau characterize a number of
neurodegenerative diseases collectively termed tauopathies. These aggregates comprise …