Roles of Kruppel-associated box (KRAB)-associated co-repressor KAP1 Ser-473 phosphorylation in DNA damage response

C Hu, S Zhang, X Gao, X Gao, X Xu, YA Lv… - Journal of Biological …, 2012 - ASBMB
The Kruppel-associated box (KRAB)-associated co-repressor KAP1 is an essential nuclear
co-repressor for the KRAB zinc finger protein superfamily of transcriptional factors. Ataxia …

The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin

C Maison, K Romeo, D Bailly, M Dubarry… - Nature structural & …, 2012 - nature.com
SUMOylation promotes targeting of HP1α to pericentric heterochromatin. Here we identify
the SUMO-specific protease SENP7 in mouse as a maintenance factor for HP1α …

Ligand-dependent Corepressor (LCoR) Recruitment by Krüppel-like Factor 6 (KLF6) regulates expression of the cyclin-dependent kinase inhibitor CDKN1A gene

MR Calderon, M Verway, BS An, A DiFeo… - Journal of Biological …, 2012 - ASBMB
The widely expressed transcriptional coregulator, ligand-dependent corepressor (LCoR),
initially characterized as a regulator of nuclear receptor-mediated transactivation, functions …

Coordinate to guard: crosstalk of phosphorylation, sumoylation, and ubiquitylation in DNA damage response

CY Kuo, C Shieh, F Cai, DK Ann - Frontiers in oncology, 2012 - frontiersin.org
Small ubiquitin-like modifier-1/2/3 (SUMO-1/2/3) and ubiquitin share similar structure and
utilize analogous machinery for protein lysine conjugation. Although sumoylation and …

Analysis of the nuclear role of RPB5 binding protein (URI/RMP) in prostate cells

P Mita - 2012 - search.proquest.com
Abstract Unconventional prefoldin RPB5 Interactor (URI) was identified as a protein that
binds the RPB5 subunit of polymerases and functions as a transcriptional repressor …

[PDF][PDF] Gene Regulation

JBCA Sites - 2012 - mcgill.ca
Background: LCoR was identified as a repressor of nuclear hormone receptors. Results: A
screen for new interacting factors revealed that LCoR acts with KLF6 to repress CDKN1A …

[图书][B] Characterization of SUMO-modified substrates by mass spectrometry

O Osula - 2012 - search.proquest.com
Abstract SUMO (Small-Ubiquitin-like MOdifier) is a post-translational modifier of protein
substrates at lysine residues that conjugates to proteins in response to various changes in …