Although the primary cause of multiple sclerosis (MS) is unknown, the widely accepted view
is that aberrant (auto) immune responses possibly arising following infection (s) are …

Hypothyroidism is a well-described cause of hypomyelination. In addition, thyroid hormone
(T3) has recently been shown to enhance remyelination in various animal models of CNS …

Multiple sclerosis (MS) is characterized by episodes of inflammatory demyelination with
progressive failure of remyelination. Prior studies using murine models of MS indicate that …

In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important
components of the lesion environment that can impact remyelination. The current study …

How iron is delivered to the CNS for myelination is not well understood. We assessed
whether astrocytes can provide iron to cells in the CNS for remyelination. To study this we …

Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS). They
develop from oligodendrocyte precursor cells and differentiate into mature myelin forming …

The loss of myelin has serious functional consequences in multiple sclerosis (MS) and other
demyelinating disorders and may place demyelinated axons at risk of subsequent …

Iron is an essential metal that is required for various biological processes. However,
excessive iron is toxic because of its ability to promote free radical formation. To prevent iron …

The CLN5 disease − protein maturation, trafficking and pathology Page 1 84 The CLN5
disease −protein ma tura tion , trafficking and pa tholog y 84 2012 M ia -Lisa S chm ie d t Mia-Lisa …

A major distinguishing feature of the vertebrate nervous system is the formation of myelin
sheaths. The myelin sheath has two main functions. First, it electrically insulates the axon …