Emerging drugs for malaria
S Tschan, PG Kremsner… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Malaria remains one of the most important infectious diseases, causing around
655 000 deaths annually, mostly among children in Sub-Saharan Africa. Plasmodium …
655 000 deaths annually, mostly among children in Sub-Saharan Africa. Plasmodium …
Selective inhibition of E. coli 1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates
JM Smith, RJ Vierling, CF Meyers - MedChemComm, 2012 - pubs.rsc.org
DXP synthase catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate, an essential
precursor in pathogen isoprenoid biosynthesis. The selective inhibition of this ThDP …
precursor in pathogen isoprenoid biosynthesis. The selective inhibition of this ThDP …
Inadequate efficacy of a new formulation of fosmidomycin-clindamycin combination in Mozambican children less than three years old with uncomplicated Plasmodium …
M Lanaspa, C Moraleda, S Machevo… - Antimicrobial agents …, 2012 - Am Soc Microbiol
The combination of fosmidomycin and clindamycin (F/C) is effective in adults and older
children for the treatment of malaria and could be an important alternative to existing …
children for the treatment of malaria and could be an important alternative to existing …
A Closer Look at the Spectroscopic Properties of Possible Reaction Intermediates in Wild-Type and Mutant (E)-4-Hydroxy-3-methylbut-2-enyl Diphosphate Reductase
W Xu, NS Lees, D Hall, D Welideniya, BM Hoffman… - Biochemistry, 2012 - ACS Publications
(E)-4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH or LytB) catalyzes the
terminal step of the MEP/DOXP pathway where it converts (E)-4-hydroxy-3-methylbut-2-enyl …
terminal step of the MEP/DOXP pathway where it converts (E)-4-hydroxy-3-methylbut-2-enyl …
Novel drug targets in malaria parasite with potential to yield antimalarial drugs with long useful therapeutic lives
FW Muregi, H Nyakio Wamakima… - Current pharmaceutical …, 2012 - ingentaconnect.com
The status of chemotherapy as the main strategy in malaria control is rapidly being eroded
by development of drug resistant Plasmodia, causing malaria to be dubbed a “re-emerging …
by development of drug resistant Plasmodia, causing malaria to be dubbed a “re-emerging …
Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 1: a …
K Mesia, L Tona, MM Mampunza… - Planta …, 2012 - thieme-connect.com
The aim of this phase IIA clinical trial was to assess the efficacy of an 80% ethanolic
quantified extract (containing 5.6% strictosamide as the putative active constituent) from …
quantified extract (containing 5.6% strictosamide as the putative active constituent) from …
Non-antifolate antibiotics: clindamycin, doxycycline, azithromycin and fosmidomycin
S Krishna, HM Staines - Treatment and Prevention of Malaria: Antimalarial …, 2012 - Springer
A range of antibiotics, in addition to those that target folate metabolism, have demonstrated
antimalarial activity. They include those belonging to the lincosamides, tetracyclines and …
antimalarial activity. They include those belonging to the lincosamides, tetracyclines and …
[PDF][PDF] Synthese und biologische Evaluation von inversen alpha-substituierten, beta-oxa-isosteren Fosmidomycin-Analoga und Derivaten mit Benzamid-Teilstruktur
K Brücher - 2012 - docserv.uni-duesseldorf.de
Plasmodium malariae (Malaria quartana), Plasmodium vivax und Plasmodium ovale
(Malaria tertiana) sowie Plasmodium falciparum (Malaria tropica). 2, 10 Während Infektionen …
(Malaria tertiana) sowie Plasmodium falciparum (Malaria tropica). 2, 10 Während Infektionen …
Computational Chemistry, Drug Design, and Drug Re-Discovery Aimed at Theory-Directed Synthesis of Cannabinoids and Computational Methods to Predict …
A Garcia - 2012 - escholarship.org
The aim of this thesis is the discovery or re-discovery of drug-like compounds having
therapeutic value; although two distinct strategies are reported, both share a strong …
therapeutic value; although two distinct strategies are reported, both share a strong …
Estudos in vitro de potenciais antimaláricos nos estágios intraeritrocítico de Plasmodium falciparum.
MF Silva - 2012 - teses.usp.br
Nesta dissertação, identificou-se que as drogas esqualestatina, fosmidomicina, risedronato
e nerolidol apresentam atividades sinérgicas e aditivas quando administradas em cultura …
e nerolidol apresentam atividades sinérgicas e aditivas quando administradas em cultura …