Molecular genetics of B-precursor acute lymphoblastic leukemia

CG Mullighan - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and
the leading cause of cancer-related death in children and young adults. The majority of B …

The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia

AV Moorman - Blood reviews, 2012 - Elsevier
Acute lymphoblastic leukaemia (ALL) occurs at all ages but is the most common cancer of
childhood. The current treatment of paediatric ALL is highly successful with up to 90 …

Risk stratification–directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell …

CH Yan, DH Liu, KY Liu, LP Xu, YR Liu… - Blood, The Journal …, 2012 - ashpublications.org
We studied the impact of risk stratification–directed interventions for minimal residual
disease (MRD) on relapse and disease-free survival (DFS) prospectively in 814 subjects …

Outcomes in older adults with acute lymphoblastic leukaemia (ALL): results from the international MRC UKALL XII/ECOG 2993 trial

JI Sive, G Buck, A Fielding, HM Lazarus… - British journal of …, 2012 - Wiley Online Library
Although the incidence rate of acute lymphoblastic leukaemia (ALL) is slightly higher in
older than in younger adults, response rates to induction chemotherapy and survival rates …

Has MRD monitoring superseded other prognostic factors in adult ALL?

M Brüggemann, T Raff, M Kneba - Blood, The Journal of the …, 2012 - ashpublications.org
Significant improvements have been made in the treatment of acute lymphoblastic leukemia
(ALL) during the past 2 decades, and measurement of submicroscopic (minimal) levels of …

Adolescents and young adults with acute lymphoblastic leukemia have a better outcome when treated with pediatric‐inspired regimens: systematic review and meta …

R Ram, O Wolach, L Vidal, A Gafter‐Gvili… - American journal of …, 2012 - Wiley Online Library
Survival of adults with acute lymphoblastic leukemia (ALL) is inferior to that of pediatric
patients. Strategies to improve the outcome of adult population are warranted. This study …

IGH@ Translocations, CRLF2 Deregulation, and Microdeletions in Adolescents and Adults With Acute Lymphoblastic Leukemia

AV Moorman, C Schwab, HM Ensor… - Journal of Clinical …, 2012 - ascopubs.org
Purpose To determine the prevalence and prognostic impact of significant acute
lymphoblastic leukemia (ALL)–related genes: CRLF2 deregulation (CRLF2-d), IGH …

Outcomes and prognostic factors of adults with acute lymphoblastic leukemia who relapse after allogeneic hematopoietic cell transplantation. An analysis on behalf of …

A Spyridonidis, M Labopin, C Schmid, L Volin… - Leukemia, 2012 - nature.com
To describe outcomes, treatment and prognostic factors that influence survival of adult
patients with acute lymphoblastic leukemia (ALL), who relapsed after allogeneic …

IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia

I Iacobucci, N Iraci, M Messina, A Lonetti, S Chiaretti… - PloS one, 2012 - journals.plos.org
Background Deletions of IKAROS (IKZF1) frequently occur in B-cell precursor acute
lymphoblastic leukemia (B-ALL) but the mechanisms by which they influence pathogenesis …

Acute lymphoblastic leukemia

JC Alvarnas, PA Brown, P Aoun, KK Ballen… - Journal of the National …, 2012 - jnccn.org
The inaugural NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for acute
lymphoblastic leukemia (ALL) were developed as a result of meetings convened by a multi …