Outcomes for heart failure (HF) patients remain suboptimal. No known therapy improves
mortality in acute HF and HF with preserved ejection fraction; the most recent HF trial results …

Nitric oxide (NO) is an essential signaling molecule in biological systems. In mammals, the
diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it …

Pulmonary vascular disease can be defined as either a disease affecting the pulmonary
capillaries and pulmonary arterioles, termed pulmonary arterial hypertension, or a disease …

The present review first summarizes the complex chain of events, in endothelial and
vascular smooth muscle cells, that leads to endothelium-dependent relaxations …

Aims Cinaciguat (BAY 58-2667) is a soluble guanylate cyclase (sGC) activator that, in a
previous study among patients with acute heart failure syndromes (AHFS), improved …

Cyclic guanosine monophosphate (cGMP) is an important intracellular second messenger
that mediates multiple tissue and cellular responses. The cGMP pathway is a key element in …

Background Fibrosis and vascular disease are cardinal features of systemic sclerosis (SSc).
Stimulators of soluble guanylate cyclase (sGC) are vasoactive drugs that are currently being …

The heme‐protein soluble guanylyl cyclase (sGC) is the intracellular receptor for nitric oxide
(NO). sGC is a heterodimeric enzyme with α and β subunits and contains a heme moiety …

Heme insertion is key during maturation of soluble guanylyl cyclase (sGC) because it
enables sGC to recognize NO and transduce its multiple biological effects. Although sGC is …

Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists
as reduced (NO-sensitive) and oxidized (NO-insensitive) forms. We tested the hypothesis …