Ovarian cancer is the most lethal gynecological malignancy. Cisplatin and its derivatives are
first‐line chemotherapeutics, and their resistance is a major hurdle in successful ovarian …

The PI3K pathway plays an important role in key cellular functions such as cell growth,
proliferation and survival. Genetic and epigenetic alterations in different pathway …

Background: Eight human catalytic phosphoinositide 3-kinase (PI3K) isoforms exist which
are subdivided into three classes. While class I isoforms have been well-studied in cancer …

Leptin, the peptide hormone product of the ob gene, regulates food intake and energy
expenditure at the hypothalamic level via the long-form of the leptin receptor (Ob-Rb). Leptin …

Phosphoinositide 3-kinases (PI3Ks) are a group of enzymes that catalyse the transfer of γ
phosphate group of ATP to the D3-position of inositol ring of phospotidylinositols (PtdIns) …

Glioblastoma represents the most common and malignant cancer of the brain. After surgical
resection, the standard of care treatment for glioblastoma includes radiation therapy and …