IL-4 has been extensively studied in the context of its role in immunity. Accumulating
evidence indicates, however, that it also plays a critical role in higher functions of the normal …

One of the more important recent advances in neuroscience research is the understanding
that there is extensive communication between the immune system and the central nervous …

The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests
that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic …

Increasing evidence highlights a role for the immune system in the pathogenesis of autism
spectrum disorder (ASD), as immune dysregulation is observed in the brain, periphery, and …

Under most physiological circumstances, monocytes are excluded from parenchymal CNS
tissues. When widespread monocyte entry occurs, their numbers decrease shortly after …

Objective. Penetrating cortical neural probe technologies allow investigators to record
electrical signals in the brain. Implantation of probes results in acute tissue damage, and …

The central nervous system (CNS) is now known to actively communicate with the immune
system to control immune responses both centrally and peripherally. Within the CNS, while …

Mutations in the X-linked gene, methyl-CpG binding protein 2 (Mecp2), underlie a wide
range of neuropsychiatric disorders, most commonly, Rett Syndrome (RTT), a severe autism …

Brain function is shaped by postnatal experience and vulnerable to disruption of Methyl-CpG-
binding protein, Mecp2, in multiple neurodevelopmental disorders. How Mecp2 contributes …

To see the cells without disturbing them, Nimmerjahn used a newly published approach for
imaging a live mouse brain1. After anaesthetizing the animal and peeling back its scalp, he …