Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …

The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases
DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation …

While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic
alterations during tumorigenesis including aberrant DNA hypermethylation of tumor …

The methylation status of the O 6-methylguanine-DNA methyltransferase (MGMT) gene is an
important predictive biomarker for benefit from alkylating agent therapy in glioblastoma …

Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a
devastating problem in the treatment of cancer patients. Multiple mechanisms contribute to …

Genome-wide microRNA (miRNA) profiling of 82 glioblastomas demonstrated that miR-181d
was inversely associated with patient overall survival after correcting for age, Karnofsky …

A biomarker is a molecular target analyzed in a qualitative or quantitative manner to detect
and diagnose the presence of a disease, to predict the outcome and the response to a …

Gliomas are the most frequent adult primary brain tumor, and are invariably fatal. The most
common diagnosis glioblastoma multiforme (GBM) afflicts 12,500 new patients in the US …

PURPOSE: Radiotherapy (RT) and chemotherapy may prolong survival in older patients
(age≥ 70 years) with glioblastoma multiforme (GBM), although the survival benefits remain …