Plasma protein C is a serine protease zymogen that is transformed into the active, trypsin-
like protease, activated protein C (APC), which can exert multiple activities. For its …

Sepsis results in the concurrent activation of inflammatory and procoagulant pathways.
Bacterial products and proinflammatory cytokines trigger the coagulation system primarily …

The efficient trafficking of immune cells into peripheral nonlymphoid tissues is key to enact
their protective functions. Despite considerable advances in our understanding of cell …

Deregulated interplay between inflammation and coagulation plays a pivotal role in the
pathogenesis of sepsis. Therapeutic approaches that simultaneously target both …

Septic syndromes are the main cause of death in the intensive care units and although the
mortality rates is slowly decreasing, the occurrence of the disease has been increasing. The …

After the discovery of the key components of the protein C (PC) pathway a beneficial effect
on survival of the infusion of activated protein C (APC) in animal models of sepsis was …

Aberrant activation of neutrophils during sepsis results in the widespread release of
proinflammatory mediators, leading to multiorgan system failure and death. However …

Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8
induced by TNF-a in human dermal micro Page 1 FOLIA HISTOCHEMICA ET CYTOBIOLOGICA …

Skin is the primary protective barrier against physical, chemical, thermal and infectious
threats in the environment. Maintaining the integrity of skin is a matter of survival. The …

INTRODUCTION: The brain is one of the first organs affected clinically in sepsis.
Microcirculatory alterations are suggested to be a critical component in the pathophysiology …