Substantial experimental data and recent clinical evidence suggesting that tissue
reperfusion is a better predictor of outcome after thrombolysis than recanalization …

Myocardial edema occurs in a large number of myocardial pathologies particularly during
ischemia–reperfusion, and may contribute to cell dysfunction and death occurring in these …

Background The pathophysiology of myocardial injury and repair in patients with ST‐
elevation myocardial infarction is incompletely understood. We investigated the …

Treatment of acute cardiac ischemia focuses on reestablishment of blood flow in coronary
arteries. However, impaired microvascular perfusion damages peri-infarct tissue, despite …

Cardioprotection, ie the reduction in infarct size by pre-, post-, or remote conditioning, has
originally been characterized in young and healthy experimental animals. Over the last two …

A multitude of factors, including increased coronary vascular resistance and dysregulated
coronary microcirculatory function, contribute to the impairment of coronary blood flow (CBF) …

Recurrent angina in patients who underwent percutaneous coronary intervention is defined
as recurrence of chest pain or chest discomfort. Careful assessment is recommended to …

Background Both infarct size and microvascular obstruction (MO) assessed by cardiac
magnetic resonance imaging (CMR) are known to be predictors for adverse clinical outcome …

Ischemic heart disease is the most frequent etiology for cardiovascular morbidity and
mortality. Early detection and accurate monitoring are essential to guide optimal patient …

OBJECTIVE: To investigate whether ischemic preconditioning (IP) can reduce myocardial no-
reflow by activating endothelial (e-) nitric oxide synthase (NOS) via the protein kinase A …