Natural killer (NK) cells were first described as immune leukocytes that could kill tumor cells
and soon after were reported to kill virus-infected cells. In the mid-1980s, 10 years after their …

Muscle wasting is a serious complication of various clinical conditions that significantly
worsens the prognosis of the illnesses. Clinically relevant models of muscle wasting are …

It has been postulated that an early systemic inflammatory response syndrome (SIRS) and a
subsequent compensatory anti-inflammatory response syndrome (CARS) occur sequentially …

Purpose End-organ apoptosis is well-described in progressive sepsis and Multiple Organ
Dysfunction Syndrome (MODS), especially where platelets accumulate (eg spleen and …

Sepsis is a disease syndrome covering many different aspects of the host immune system.
Our understanding of sepsis is still incomplete. Several animal models of sepsis have been …

Early during Gramnegative sepsis, excessive release of proinflammatory cytokines can
cause septic shock that is often followed by a state of immune paralysis characterized by the …

Although global MyD88 deficiency attenuates lethal inflammation in sepsis, cell-specific
functions of MyD88 remain largely unknown. Using mice with selective expression of MyD88 …

The neuropeptide CGRP contributes to the control of excessive cytokine production in
endotoxemia models. However, the function of CGRP in sepsis caused by infection with …

The objective of the study was to investigate the mechanisms of insufficient interferon-γ (IFN-
γ) response to interleukin 18 (IL-18) and the treatment for the insufficient response in septic …

Sepsis is a devastating condition characterized by the systemic activation of inflammatory
and coagulation pathways in response to microbial infection of normally sterile parts of the …