From the 19th century to the present, the complex indole alkaloid strychnine has engaged
the chemical community. In this Review, we examine why strychnine has been and remains …

In the long lasting battle against cancer, Nature sometimes gives a helping hand to
researchers to find new drugs for the treatment of diseases and improvement of patients …

In biology-oriented synthesis, the scaffolds of biologically relevant compound classes inspire
the synthesis of focused compound collections enriched in bioactivity. This criterion is, in …

The selection, acquisition, and use of high‐quality small molecule libraries for screening is
an essential aspect of drug discovery and chemical biology programs. Screening libraries …

An asymmetric inverse-electron-demand Diels–Alder reaction of chromone-fused dienes
and β, β-disubstituted α, β-unsaturated aldehydes has been developed via dienamine …

The discovery of new compounds for the pharmacological manipulation of protein function
often embraces the screening of compound collections, and it is widely recognized that …

A strategy directed towards the total synthesis of isatisine A that involves several late‐stage
metal‐catalyzed transformations that address the key carbon–carbon and carbon …

The first organocatalytic asymmetric assembly of Morita–Baylis–Hillman carbonates of
isatins and α-angelica lactone has been studied, affording multifunctional products …

The asymmetric Michael addition of dioxindoles to β-substituted nitroalkenes is reported.
The bifunctional primary amine-thiourea A, by means of a non-covalent-based mode of …

The rapidly expanding field of gold and platinum π-acid catalysis has led to the discovery of
diverse transformations that are initiated with nucleophilic attack onto a metal-activated …