Drug-induced QT interval prolongation: mechanisms and clinical management
S Nachimuthu, MD Assar… - Therapeutic advances in …, 2012 - journals.sagepub.com
The prolonged QT interval is both widely seen and associated with the potentially deadly
rhythm, Torsades de Pointes (TdP). While it can occur spontaneously in the congenital form …
rhythm, Torsades de Pointes (TdP). While it can occur spontaneously in the congenital form …
Clinical use of antidepressant therapy and associated cardiovascular risk
WS Waring - Drug, healthcare and patient safety, 2012 - Taylor & Francis
A number of different psychotropic agents have been associated with an increased risk of
cardiovascular disease, and these relationships have been difficult to interpret due to the …
cardiovascular disease, and these relationships have been difficult to interpret due to the …
Utility of the electrocardiogram in drug overdose and poisoning: theoretical considerations and clinical implications
C Yates, AF Manini - Current cardiology reviews, 2012 - ingentaconnect.com
The ECG is a rapidly available clinical tool that can help clinicians manage poisoned
patients. Specific myocardial effects of cardiotoxic drugs have well-described …
patients. Specific myocardial effects of cardiotoxic drugs have well-described …
Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal
F van Gorp, S Duffull, LP Hackett… - British journal of clinical …, 2012 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Escitalopram is a selective serotonin
re‐uptake inhibitor and the S‐enantiomer of racemic citalopram. Previous studies have …
re‐uptake inhibitor and the S‐enantiomer of racemic citalopram. Previous studies have …
Pharmacotherapeutic determinants for QTc interval prolongation in Japanese patients with mood disorder
H Okayasu, Y Ozeki, K Fujii, Y Takano… - …, 2012 - thieme-connect.com
An increased incidence of sudden death has been observed among patients treated with
antidepressants. A prolonged QTc interval is a known prognostic factor for fatal arrhythmia …
antidepressants. A prolonged QTc interval is a known prognostic factor for fatal arrhythmia …
[PDF][PDF] The relation between arterial blood pressure variables and ventricular repolarization parameters
I Mozos, C Serban, R Mihaescu - International Journal of …, 2012 - researchgate.net
Introduction: Ventricular arrhythmia and sudden cardiac death risk are associated with
prolonged electrocardiographic (ECG) QT and Tpeak-Tend intervals. Objective: To evaluate …
prolonged electrocardiographic (ECG) QT and Tpeak-Tend intervals. Objective: To evaluate …
Determination of torsade-causing potential of drug candidates using one-class classification and ensemble modelling approaches
Y He, S Wen Yan Lim, C Wei Yap - Current drug safety, 2012 - ingentaconnect.com
Adverse drug reactions (ADRs) are a main problem faced by drug companies and regulatory
authorities. Not only do they contribute heavily to late-phase failure of drug development and …
authorities. Not only do they contribute heavily to late-phase failure of drug development and …
Individual patient assessment of methadone-induced QT prolongation with digital holter recording
A 27-year-old male who had been on methadone therapy for 6 months was investigated with
a 12-lead digital holter because of a prolonged QT on a standard 12-lead electrocardiogram …
a 12-lead digital holter because of a prolonged QT on a standard 12-lead electrocardiogram …
What are the values of using QTc and N-terminal fragment of B-type natriuretic peptide as markers for early detection of acute antipsychotic drugs-induced …
H Sanaei-Zadeh - Cardiovascular toxicology, 2012 - Springer
I have read with great interest the study carried out by Khalaf et al.[1] published in
Cardiovascular Toxicology. They evaluated the role of the N-terminal fragment of B-type …
Cardiovascular Toxicology. They evaluated the role of the N-terminal fragment of B-type …
Acute intoxication with the adjuvant itself for Gramoxone INTEON
JM Moon, BJ Chun - Human & experimental toxicology, 2012 - journals.sagepub.com
The adjuvant for Gramoxone INTEON is composed of 20% methanol, 20% sodium lingo
sulphonate, 10% alkylaryl polyoxyethylene ether, and 50% water. Although the adjuvant is a …
sulphonate, 10% alkylaryl polyoxyethylene ether, and 50% water. Although the adjuvant is a …