Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke,
and peripheral vascular disease, continue to be among the most frequent causes of …

Many advances have been achieved in terms of understanding the molecular and cellular
mechanisms of ischemic stroke. But thus far, clinically effective neuroprotectants remain …

Inflammation is a hallmark of stroke pathology. The cytokines, tumor necrosis factor (TNF),
interleukin (IL)-1, and IL-6, modulate tissue injury in experimental stroke and are therefore …

Laser speckle contrast imaging (LSCI) has emerged over the past decade as a powerful, yet
simple, method for imaging of blood flow dynamics in real time. The rapid adoption of LSCI …

Objective: To evaluate the value of continuous electroencephalography in early
prognostication in patients treated with hypothermia after cardiac arrest. Design: Prospective …

Throughout the history of research on stroke pathophysiology, focus has shifted from purely
vascular concepts to the insight that a complex interplay of biochemical and molecular …

Anoxic depolarization of pyramidal neurons results from a large inward current that is
activated, in part, by excessive glutamate release during exposure to anoxia/ischemia …

Inflammation is a highly dynamic and complex adaptive process to preserve and restore
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …

Secondary injury is a term applied to the destructive and self-propagating biological
changes in cells and tissues that lead to their dysfunction or death over hours to weeks after …

Inflammatory processes in the central nervous system play an important role in a number of
neurodegenerative diseases mediated by microglial activation, which results in neuronal …