Genomic instability is one of the most pervasive characteristics of tumour cells and is
probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a …

Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

Clinical responses to anticancer therapies are often restricted to a subset of patients. In
some cases, mutated cancer genes are potent biomarkers for responses to targeted agents …

Cellular stress responses are mediated through a series of regulatory processes that occur
at the genomic, transcriptional, post-transcriptional, translational, and post-translational …

PARP inhibitors are active in tumors with defects in DNA homologous recombination (HR)
due to BRCA1/2 mutations. The phosphoinositide 3-kinase (PI3K) signaling pathway …

PARP-1 is an abundant nuclear enzyme that modifies substrates by poly (ADP-ribose)-
ylation. PARP-1 has well-described functions in DNA damage repair and also functions as a …

Since the introduction of serum prostate-specific antigen (PSA) screening 25 years ago,
prostate cancer diagnosis and management have been guided by this biomarker. Yet, PSA …

Background: Whether the genomic rearrangement transmembrane protease, serine 2
(TMPRSS2): v-ets erythroblastosis virus E26 oncogene homolog (ERG) has prognostic …

The homologous ETV1, ETV4 and ETV5 proteins form the PEA3 subfamily of ETS
transcription factors. In Ewing tumors, chromosomal translocations affecting ETV1 or ETV4 …

The poly (ADP-ribose) polymerase (PARP) protein superfamily has wide-ranging roles in
cellular processes such as DNA repair and WNT signalling. Efforts to pharmacologically …