Detecting natural selection in genomic data
JJ Vitti, SR Grossman, PC Sabeti - Annual review of genetics, 2013 - annualreviews.org
The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …
methods to identify genomic regions that appear to be shaped by natural selection. These …
Population genomics of rapid adaptation by soft selective sweeps
Organisms can often adapt surprisingly quickly to evolutionary challenges, such as the
application of pesticides or antibiotics, suggesting an abundant supply of adaptive genetic …
application of pesticides or antibiotics, suggesting an abundant supply of adaptive genetic …
Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars
We report the sequencing at 131× coverage, de novo assembly and analyses of the genome
of a female Tibetan wild boar. We also resequenced the whole genomes of 30 Tibetan wild …
of a female Tibetan wild boar. We also resequenced the whole genomes of 30 Tibetan wild …
Robust identification of local adaptation from allele frequencies
Comparing allele frequencies among populations that differ in environment has long been a
tool for detecting loci involved in local adaptation. However, such analyses are complicated …
tool for detecting loci involved in local adaptation. However, such analyses are complicated …
Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden
Despite advances in sequencing, the goal of obtaining a comprehensive view of genetic
variation in populations is still far from reached. We sequenced 180 lines of A. thaliana from …
variation in populations is still far from reached. We sequenced 180 lines of A. thaliana from …
[HTML][HTML] Identifying recent adaptations in large-scale genomic data
Although several hundred regions of the human genome harbor signals of positive natural
selection, few of the relevant adaptive traits and variants have been elucidated. Using full …
selection, few of the relevant adaptive traits and variants have been elucidated. Using full …
Detecting signatures of selection through haplotype differentiation among hierarchically structured populations
MI Fariello, S Boitard, H Naya, M SanCristobal… - Genetics, 2013 - academic.oup.com
The detection of molecular signatures of selection is one of the major concerns of modern
population genetics. A widely used strategy in this context is to compare samples from …
population genetics. A widely used strategy in this context is to compare samples from …
Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation
The panda lineage dates back to the late Miocene and ultimately leads to only one extant
species, the giant panda (Ailuropoda melanoleuca). Although global climate change and …
species, the giant panda (Ailuropoda melanoleuca). Although global climate change and …
Calculation of Tajima's D and other neutrality test statistics from low depth next-generation sequencing data
Background A number of different statistics are used for detecting natural selection using
DNA sequencing data, including statistics that are summaries of the frequency spectrum …
DNA sequencing data, including statistics that are summaries of the frequency spectrum …
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
KL Monda, GK Chen, KC Taylor, C Palmer… - Nature …, 2013 - nature.com
Genome-wide association studies (GWAS) have identified 36 loci associated with body
mass index (BMI), predominantly in populations of European ancestry. We conducted a …
mass index (BMI), predominantly in populations of European ancestry. We conducted a …