How good is automated protein docking?
The protein docking server ClusPro has been participating in critical assessment of
prediction of interactions (CAPRI) since its introduction in 2004. This article evaluates the …
prediction of interactions (CAPRI) since its introduction in 2004. This article evaluates the …
Hepatitis C virus E2 envelope glycoprotein core structure
Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and
hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry …
hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry …
Interactions of the α-subunits of heterotrimeric G-proteins with GPCRs, effectors and RGS proteins: a critical review and analysis of interacting surfaces, conformational …
FA Baltoumas, MC Theodoropoulou… - Journal of structural …, 2013 - Elsevier
G-protein coupled receptors (GPCRs) are one of the largest families of membrane receptors
in eukaryotes. Heterotrimeric G-proteins, composed of α, β and γ subunits, are important …
in eukaryotes. Heterotrimeric G-proteins, composed of α, β and γ subunits, are important …
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ
S Alex, K Lange, T Amolo, JS Grinstead… - … and cellular biology, 2013 - Taylor & Francis
Angiopoietin-like protein 4 (ANGPTL4/FIAF) has been proposed as a circulating mediator
between the gut microbiota and fat storage. Here, we show that transcription and secretion …
between the gut microbiota and fat storage. Here, we show that transcription and secretion …
[HTML][HTML] Advances in integrative modeling of biomolecular complexes
E Karaca, AMJJ Bonvin - Methods, 2013 - Elsevier
High-resolution structural information is needed in order to unveil the underlying
mechanistic of biomolecular function. Due to the technical limitations or the nature of the …
mechanistic of biomolecular function. Due to the technical limitations or the nature of the …
[HTML][HTML] A unified conformational selection and induced fit approach to protein-peptide docking
Protein-peptide interactions are vital for the cell. They mediate, inhibit or serve as structural
components in nearly 40% of all macromolecular interactions, and are often associated with …
components in nearly 40% of all macromolecular interactions, and are often associated with …
[PDF][PDF] Mixed-linkage ubiquitin chains send mixed messages
MA Nakasone, N Livnat-Levanon, MH Glickman… - Structure, 2013 - cell.com
Research on ubiquitin (Ub) signaling has focused primarily on homogeneously linked
polyUb. Although polyUb containing different linkages within the same chain exist, their …
polyUb. Although polyUb containing different linkages within the same chain exist, their …
Crystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases
Nonribosomal peptide synthetases (NRPSs) are large modular macromolecular machines
that produce small peptide molecules with wide-ranging biological activities, such as …
that produce small peptide molecules with wide-ranging biological activities, such as …
Allosteric regulation of E2: E3 interactions promote a processive ubiquitination machine
RING finger proteins constitute the large majority of ubiquitin ligases (E3s) and function by
interacting with ubiquitin‐conjugating enzymes (E2s) charged with ubiquitin. How low …
interacting with ubiquitin‐conjugating enzymes (E2s) charged with ubiquitin. How low …
[HTML][HTML] Binding of PHF1 Tudor to H3K36me3 enhances nucleosome accessibility
The Tudor domain of human PHF1 recognizes trimethylated lysine 36 of histone H3
(H3K36me3). This interaction modulates the methyltransferase activity of the PRC2 complex …
(H3K36me3). This interaction modulates the methyltransferase activity of the PRC2 complex …