Regulation of the DNA damage response by cyclin-dependent kinases
C Trovesi, N Manfrini, M Falcettoni… - Journal of molecular …, 2013 - Elsevier
The eukaryotic cell cycle comprises a series of events, whose ordering and correct
progression depends on the oscillating activity of cyclin-dependent kinases (Cdks), which …
progression depends on the oscillating activity of cyclin-dependent kinases (Cdks), which …
[PDF][PDF] Dissection of DNA damage responses using multiconditional genetic interaction maps
To protect the genome, cells have evolved a diverse set of pathways designed to sense,
signal, and repair multiple types of DNA damage. To assess the degree of coordination and …
signal, and repair multiple types of DNA damage. To assess the degree of coordination and …
Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1
The mediators of the DNA damage response (DDR) are highly phosphorylated by kinases
that control cell proliferation, but little is known about the role of this regulation. Here we …
that control cell proliferation, but little is known about the role of this regulation. Here we …
DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast
Double-strand breaks (DSBs) in budding yeast trigger activation of DNA damage
checkpoints, allowing repair to occur. Although resection is necessary for initiating damage …
checkpoints, allowing repair to occur. Although resection is necessary for initiating damage …