Introduction Inflammation is a very important part of innate immunity and is regulated in
many steps. One such regulating step is the cytokine network, where tumor necrosis factor α …

Chemotherapeutic agents-and radiation therapy-induced NF-κB activation in cancer cells
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …

Abstract Treatment failure in high risk neuroblastoma is largely due to development of
chemoresistance. NF-κB activation is one of the resistance mechanisms for cancer cells to …

Hyperhomocysteinemia is a risk factor for osteoporotic fractures. Homocysteine (Hcys)
inhibits collagen cross‐linking and consequently decreases bone extracellular matrix (ECM) …

Aims Atherosclerosis is a public health concern affecting many worldwide, but its
pathogenesis remains unclear. In this study we investigated the role of IKKε during the …

Hyperproduction of mucin in the nasal epithelium is an important feature of nasal
inflammatory diseases. We investigated the mechanism of lipopolysaccharides (LPS) …

Intracellular replication of Salmonella enterica requires effector proteins translocated across
the Salmonella-containing vacuolar membrane by Salmonella pathogenicity island-2 (SPI-2) …

Pro-inflammatory and pro-apoptotic mediators have been involved in the pathogenesis of
neurodegenerative diseases. Tigecycline (Tig), a glycylcycline antibiotic and an analog of …

CUEDC2, a newly reported protein, has been found to be ubiquitously expressed in human
tissues and repress NF-κB activity. To study the role of CUEDC2 in chronic myeloid …

Dynamic simulation, based on modelling, has a significant role during to the process of
vehicle development. It is especially important in the first stages of vehicle design, when …