With a prevalence of 5.8 million in the United States alone, heart failure (HF) is associated
with high morbidity, mortality, and healthcare expenditures. Close to 1 million …

Abstract The 2012 Canadian Cardiovascular Society Heart Failure (HF) Guidelines Update
provides management recommendations for acute and chronic HF. In 2006, the Canadian …

1.1. Methodology and Evidence Review The recommendations listed in this document are,
whenever possible, evidence based. An extensive evidence review was conducted through …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted through October 2011 and includes selected …

Importance To better guide strategies intended to reduce high rates of 30-day readmission
after hospitalization for heart failure (HF), acute myocardial infarction (MI), or pneumonia …

Background Serelaxin, recombinant human relaxin-2, is a vasoactive peptide hormone with
many biological and haemodynamic effects. In a pilot study, serelaxin was safe and well …

Importance Small studies suggest that low-dose dopamine or low-dose nesiritide may
enhance decongestion and preserve renal function in patients with acute heart failure and …

Objectives: The aim of this study was to assess the effects of serelaxin on short-term
changes in markers of organ damage and congestion and relate them to 180-day mortality …

Endpoint selection is a critically important step in clinical trial design. It poses major
challenges for investigators, regulators, and study sponsors, and it also has important …

Combined dysfunction of the heart and the kidneys, which can be associated with
haemodynamic impairment, is classically referred to as cardiorenal syndrome (CRS) …