Peptide antimicrobials: cell wall as a bacterial target
NY Yount, MR Yeaman - Annals of the New York Academy of …, 2013 - Wiley Online Library
Endogenous host defense peptides (HDPs) are among the most ancient immune mediators,
constituting a first line of defense against invading pathogens across the evolutionary …
constituting a first line of defense against invading pathogens across the evolutionary …
Molecular bacteria-fungi interactions: effects on environment, food, and medicine
K Scherlach, K Graupner… - Annual review of …, 2013 - annualreviews.org
This review focuses on bacteria-fungi interactions mediated by secondary metabolites that
occur in the environment and have implications for medicine and biotechnology. Bipartite …
occur in the environment and have implications for medicine and biotechnology. Bipartite …
A unified conformational selection and induced fit approach to protein-peptide docking
Protein-peptide interactions are vital for the cell. They mediate, inhibit or serve as structural
components in nearly 40% of all macromolecular interactions, and are often associated with …
components in nearly 40% of all macromolecular interactions, and are often associated with …
Analysis of the mechanism of action of potent antibacterial hetero-tri-organometallic compounds: a structurally new class of antibiotics
Two hetero-tri-organometallic compounds with potent activity against Gram-positive bacteria
including multi-resistant Staphylococcus aureus (MRSA) were identified. The compounds …
including multi-resistant Staphylococcus aureus (MRSA) were identified. The compounds …
Targeting Mycobacterium tuberculosis and other microbial pathogens using improved synthetic antibacterial peptides
S Ramón-García, R Mikut, C Ng, S Ruden… - Antimicrobial agents …, 2013 - Am Soc Microbiol
The lack of effective therapies for treating tuberculosis (TB) is a global health problem. While
Mycobacterium tuberculosis is notoriously resistant to most available antibiotics, we …
Mycobacterium tuberculosis is notoriously resistant to most available antibiotics, we …
Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets
ML Miller, EJ Molinelli, JS Nair, T Sheikh, R Samy… - Science …, 2013 - science.org
Dedifferentiated liposarcoma (DDLS) is a rare but aggressive cancer with high recurrence
and low response rates to targeted therapies. Increasing treatment efficacy may require …
and low response rates to targeted therapies. Increasing treatment efficacy may require …
The Genome and Development-Dependent Transcriptomes of Pyronema confluens: A Window into Fungal Evolution
Fungi are a large group of eukaryotes found in nearly all ecosystems. More than 250 fungal
genomes have already been sequenced, greatly improving our understanding of fungal …
genomes have already been sequenced, greatly improving our understanding of fungal …
[HTML][HTML] Real-time attack of LL-37 on single Bacillus subtilis cells
KJ Barns, JC Weisshaar - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
Time-lapse fluorescence microscopy of single, growing Bacillus subtilis cells with 2–12s
time resolution reveals the mechanisms of antimicrobial peptide (AMP) action on a Gram …
time resolution reveals the mechanisms of antimicrobial peptide (AMP) action on a Gram …
Lipid-II forms potential “landing terrain” for lantibiotics in simulated bacterial membrane
Bacterial cell wall is targeted by many antibiotics. Among them are lantibiotics, which realize
their function via interaction with plasma membrane lipid-II molecule—a chemically …
their function via interaction with plasma membrane lipid-II molecule—a chemically …
Turning defense into offense: defensin mimetics as novel antibiotics targeting lipid II
We have previously reported on the functional interaction of Lipid II with human alpha-
defensins, a class of antimicrobial peptides. Lipid II is an essential precursor for bacterial cell …
defensins, a class of antimicrobial peptides. Lipid II is an essential precursor for bacterial cell …