Review of recent advances on post-translational modifications that determine the role of
HMGB1 as a cytokine mediator. HMGB1 is a ubiquitous nuclear protein present in almost all …

Forty years ago, high mobility group box 1 (HMGB1) was discovered in calf thymus and
named according to its electrophoretic mobility in polyacrylamide gels. Now, we know that …

BACKGROUND & AIMS: The aim of this study was to identify protective mechanisms of cold
machine perfusion in liver grafts donated after cardiac death. METHODS: Pig livers exposed …

HMGB1 is a nuclear protein that is released or secreted following trauma or severe cellular
stress. Extracellular HMGB1 triggers inflammation and recruits leukocytes to the site of tissue …

Background & Aims The use of livers from donors after cardiac arrest (DCD) is increasing in
many countries to overcome organ shortage. Due to additional warm ischemia before …

High mobility group box 1 (HMGB1) is a DNA-binding protein that possesses cytokinelike,
proinflammatory properties when released extracellularly in the C23–C45 disulfide form …

Significance: Phagocytosis is required for the clearance of dying cells. The subsequent
regulation of inflammatory responses by phagocytic cells is mediated by both innate and …

High mobility group box 1 (HMGB1), an evolutionarily highly conserved and abundant
nuclear protein also has roles within the cytoplasm and as an extracellular damage …

Sepsis is caused by an overwhelming immune response to bacterial infection. The discovery
of high mobility group box 1 (HMGB1) as a late mediator of lethal sepsis has prompted …

The tumor microenvironment is a complex system that involves the interaction between
malignant and neighbor stromal cells embedded in a mesh of extracellular matrix (ECM) …