New horizons for diagnostics and therapeutic applications of graphene and graphene oxide

L Feng, L Wu, X Qu - Advanced Materials, 2013 - Wiley Online Library
Graphene, a one‐atom‐thick two‐dimensional (2D) layer of sp2‐bonded carbon, has
received worldwide attention owing to its extraordinary physical and chemical properties …

Targeting human telomeric higher-order DNA: dimeric G-quadruplex units serve as preferred binding site

C Zhao, L Wu, J Ren, Y Xu, X Qu - Journal of the American …, 2013 - ACS Publications
Long human telomeric fragments can form stable, higher-order G-quadruplex structures,
recently identified in human cells, which are potential drug targets. However, there are very …

Structural studies on dinuclear ruthenium (II) complexes that bind diastereoselectively to an antiparallel folded human telomere sequence

T Wilson, PJ Costa, V Félix… - Journal of medicinal …, 2013 - ACS Publications
We report DNA binding studies of the dinuclear ruthenium ligand [{Ru (phen) 2} 2tpphz] 4+
in enantiomerically pure forms. As expected from previous studies of related complexes …

Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?

V Brabec, SE Howson, RA Kaner, RM Lord… - Chemical …, 2013 - pubs.rsc.org
Enantiomers of a relatively rigid DNA-binding metallo-helix are shown to have comparable
activity to that of cisplatin against the cell lines MCF7 (human breast adenocarcinoma) and …

Recent progress in G-quadruplex DNA in deep eutectic solvent

C Zhao, X Qu - Methods, 2013 - Elsevier
Guanine-rich nucleic acids are known to form four-stranded G-quadruplex structures which
are attracting increasing attention in diverse areas such as biology, medicinal chemistry …

G-quadruplexes form ultrastable parallel structures in deep eutectic solvent

C Zhao, J Ren, X Qu - Langmuir, 2013 - ACS Publications
G-quadruplex DNA is highly polymorphic. Its conformation transition is involved in a series of
important life events. These controllable diverse structures also make G-quadruplex DNA a …

Studies of ruthenium (ii)-2, 2′-bisimidazole complexes on binding to G-quadruplex DNA and inducing apoptosis in HeLa cells

Y Xia, Q Chen, X Qin, D Sun, J Zhang… - New Journal of Chemistry, 2013 - pubs.rsc.org
Three ruthenium (II) complexes [Ru (bpy) 2 (biim)] 2+(1),[Ru (phen) 2 (biim)] 2+(2) and [Ru
(p-mopip) 2-(biim)] 2+(3)(where bpy is 2, 2′-bipyridine, phen is 1, 10-phenanthroline, biim …

A new light-scattering sensor for screening G-quadruplex stabilizers based on DNA-folding-mediated assembly of gold nanoparticles

DQ Feng, G Liu, W Zheng, T Chen, D Li - Journal of Materials …, 2013 - pubs.rsc.org
In this contribution, we constructed a biosensor for screening G-quadruplex stabilizers
based on the assembly of gold nanoparticles functionalized with guanine-rich (G-rich) …

Synthesis, characterization, and DNA-binding of enantiomers of iron (II) Schiff base complexes

ZG Gu, JJ Na, FF Bao, XX Xu, W Zhou, CY Pang, Z Li - Polyhedron, 2013 - Elsevier
Two pairs of iron (II) chiral enantiomers fac-Δ-[Fe (S-L1) 3][ClO4] 2 and fac-Λ-[Fe (R-L1)
3][ClO4] 2 (Δ-1 and Λ-1), fac-Δ-[Fe (S-L2) 3][ClO4] 2 and fac-Λ-[Fe (R-L2) 3][ClO4] 2 (Δ-2 and …

Stabilization of G-quadruplex DNA and antitumor activity by different structures of nickel (II) complexes

F Le, D Sun, D Liu, C Zheng, Y Liu, J Liu - Inorganic Chemistry …, 2013 - Elsevier
In the present investigation, four nickel (II) complexes [Ni (bpy) 3] 2+ NB,[Ni (phen) 3] 2+
NP,[Ni (bpy) 2 (p-ipip)] 2+ NBH and [Ni (phen) 2 (p-ipip)] 2+ NPH were synthesized and …