Therapeutic vaccines represent a viable option for active immunotherapy of cancers that aim
to treat late stage disease by using a patient's own immune system. The promising results …

Clearance of apoptotic cells is the final stage of programmed cell death. Uncleared corpses
can become secondarily necrotic, promoting inflammation and autoimmunity. Remarkably …

Certain chemotherapeutic regimens trigger cancer cell death while inducing dendritic cell
maturation and subsequent immune responses. However, chemotherapy‐induced …

Calreticulin is a calcium-binding chaperone that has several functions in the immune
response. In the endoplasmic reticulum (ER), calreticulin facilitates the folding of major …

Preclinical and clinical findings suggest that tumor-specific immune responses may be
responsible–at least in part–for the clinical success of therapeutic regimens that rely on …

Toll-like receptors (TLRs) have long been known for their ability to initiate innate immune
responses upon exposure to conserved microbial components such as lipopolysaccharide …

Oncolytic adenoviruses and certain chemotherapeutics can induce autophagy and
immunogenic cancer cell death. We hypothesized that the combination of oncolytic …

High-amplitude electric pulses of nanosecond duration, also known as nanosecond pulsed
electric field (nsPEF), are a novel modality with promising applications for cell stimulation …

In a recent issue of Cell Death and Differentiation, Ko and colleagues investigated how the
genetic inhibition of autophagy would impact on the response of human and murine lung …

Immunogenic Cell Death (ICD) could represent the keystone in cancer management since
tumor cell death induction is crucial as well as the control of cancer cells revival after …