End points and trial design in geriatric oncology research: a joint European organisation for research and treatment of cancer–Alliance for Clinical Trials in Oncology …

H Wildiers, M Mauer, A Pallis, A Hurria… - Journal of Clinical …, 2013 - ascopubs.org
Selecting the most appropriate end points for clinical trials is important to assess the value of
new treatment strategies. Well-established end points for clinical research exist in oncology …

Patient income level and cancer clinical trial participation

JM Unger, DL Hershman, KS Albain… - Journal of Clinical …, 2013 - ascopubs.org
Purpose Studies have shown an association between socioeconomic status (SES) and
quality of oncology care, but less is known about the impact of patient SES on clinical trial …

[HTML][HTML] Age is a prognostic factor affecting survival in lung cancer patients

F Tas, R Ciftci, L Kilic, S Karabulut - Oncology letters, 2013 - spandidos-publications.com
Despite all efforts at management, prognosis of advanced lung cancer is extremely poor,
with a median survival time of~ 1 year. The number of cancer patients aged> 70 years is …

[HTML][HTML] The challenges of enrolling older adults into intervention studies

NA Knechel - The Yale journal of biology and medicine, 2013 - ncbi.nlm.nih.gov
Adults aged 65 years or older have been routinely and systematically excluded from
research. With the number of older adults at a record high and growing faster than any other …

The treatment of glioblastomas: a systematic update on clinical Phase III trials

A Yin, J Cheng, X Zhang, B Liu - Critical reviews in oncology/hematology, 2013 - Elsevier
Glioblastomas (GBMs) are invariably associated with unavoidable tumor recurrence and
overall poor prognosis. The present study is to summarize the results of clinical Phase III …

[HTML][HTML] Elderly patients with advanced NSCLC in phase III clinical trials: are the elderly excluded from practice-changing trials in advanced NSCLC?

AG Sacher, LW Le, NB Leighl, LE Coate - Journal of Thoracic Oncology, 2013 - Elsevier
Introduction Elderly patients constitute the majority of patients with advanced non–small-cell
lung cancer (NSCLC). The median age of newly diagnosed patients with lung cancer in the …

An increasing use of defunctioning stomas after low anterior resection for rectal cancer. Is this the way to go?

HS Snijders, CBM Van den Broek, M Wouters… - European Journal of …, 2013 - Elsevier
BACKGROUND: The last decade there has been an increased awareness of the problem of
anastomotic leakage after low anterior resection for rectal cancer, which may have led to …

Elderly patients with colon cancer have unique tumor characteristics and poor survival

SS Patel, R Nelson, J Sanchez, W Lee, L Uyeno… - Cancer, 2013 - Wiley Online Library
BACKGROUND: The incidence of colon cancer increases with age, and colon cancer
predominantly affects individuals> 65 years old. However, there are limited data regarding …

Short‐term outcomes of craniotomy for malignant brain tumors in the elderly

A Seicean, S Seicean, NK Schiltz, N Alan, PK Jones… - Cancer, 2013 - Wiley Online Library
BACKGROUND. Disparity in resection rates for malignant brain tumors in elderly patients is
partially attributed to a belief that advanced age is associated with an increased risk of …

Effect of patient socioeconomic status on access to early-phase cancer trials

A Mohd Noor, D Sarker, S Vizor… - Journal of Clinical …, 2013 - ascopubs.org
Purpose Little is known about the influence of socioeconomic factors on patient access to
cancer trials. Differences should be considered to ensure generalizability of trial results and …