In response to cellular and environmental stresses, mitochondria undergo morphology
transitions regulated by dynamic processes of membrane fusion and fission. These events of …

The studies addressing the molecular mechanisms governing mitochondrial fusion and
fission have brought to light a small group of dynamin-like GTPases (Guanosine …

Respiratory chain complexes assemble into functional quaternary structures called
supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae …

Retinal ganglion cells (RGCs) project their long axons, composing the optic nerve, to the
brain, transmitting the visual information gathered by the retina, ultimately leading to formed …

Over the past decade, mitochondria have emerged as critical integrators of energy
production, generation of reactive oxygen species (ROS), multiple cell death, and signaling …

Mitochondrial morphology and metabolism play an important role in cellular homeostasis.
Recent studies have shown that the fidelity of mitochondrial morphology is important in …

Sir, Last year we reported our experience on idebenone therapy in patients with Leber's
herediatary optic neuropathy (Carelli et al., 2011), presenting results similar with those …

Mitochondrial fission has been reported to be involved in oxidative stress, apoptosis and
many neurological diseases. However, the role of mitochondrial fission in seizures, which …

Sir, We have read with interest the article by Yu-Wai-Man et al.(2010) reporting
heterogeneous multi-system manifestations in 104 patients affected with autosomal …

Major advancements have been achieved in delivering mtDNA to mitochondria and
generating faithful animal models of mtDNA-based optic neuropathy. The availability of …