The biology of thymic stromal lymphopoietin (TSLP)
SF Ziegler, F Roan, BD Bell, TA Stoklasek… - Advances in …, 2013 - Elsevier
Originally shown to promote the growth and activation of B cells, thymic stromal
lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic …
lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic …
The structural basis of direct glucocorticoid-mediated transrepression
WH Hudson, C Youn, EA Ortlund - Nature structural & molecular …, 2013 - nature.com
A newly discovered negative glucocorticoid response element (nGRE) mediates DNA-
dependent transrepression by the glucocorticoid receptor (GR) across the genome and has …
dependent transrepression by the glucocorticoid receptor (GR) across the genome and has …
Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine important for the
initiation and development of T helper (Th2) cell-mediated allergic inflammation. In this …
initiation and development of T helper (Th2) cell-mediated allergic inflammation. In this …
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses
BD Bell, M Kitajima, RP Larson, TA Stoklasek… - Nature …, 2013 - nature.com
Dendritic cells (DCs) are critical in immune responses, linking innate and adaptive immunity.
We found here that DC-specific deletion of the transcription factor STAT5 was not critical for …
We found here that DC-specific deletion of the transcription factor STAT5 was not critical for …
The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells
Summary Interleukin-21 (IL-21) has broad actions on T and B cells, but its actions in innate
immunity are poorly understood. Here we show that IL-21 induced apoptosis of conventional …
immunity are poorly understood. Here we show that IL-21 induced apoptosis of conventional …
The NF‐κ B binding site located in the proximal region of the TSLP promoter is critical for TSLP modulation in human intestinal epithelial cells
A Cultrone, T De Wouters, O Lakhdari… - European Journal of …, 2013 - Wiley Online Library
Thymic stromal lymphopoietin (TSLP) is constitutively secreted by intestinal epithelial cells. It
regulates gut DC s, therefore, contributing to the maintenance of immune tolerance. In the …
regulates gut DC s, therefore, contributing to the maintenance of immune tolerance. In the …
IL7Rα contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages
JJ Ashbaugh, R Brambilla, SA Karmally… - The Journal of …, 2013 - journals.aai.org
A mutation in the IL7Rα locus has been identified as a risk factor for multiple sclerosis (MS),
a neurodegenerative autoimmune disease characterized by inflammation, demyelination …
a neurodegenerative autoimmune disease characterized by inflammation, demyelination …
Altered responses to homeostatic cytokines in patients with idiopathic CD4 lymphocytopenia
F Bugault, D Benati, L Mouthon, I Landires, P Rohrlich… - PloS one, 2013 - journals.plos.org
Idiopathic CD4 lymphocytopenia (ICL) is a rare immune deficiency characterized by a
protracted CD4+ T cell loss of unknown etiology and by the occurrence of opportunistic …
protracted CD4+ T cell loss of unknown etiology and by the occurrence of opportunistic …
Thymic stromal lymphopoietin enhances Th2/Th22 and reduces IL‐17A in protease‐allergen‐induced airways inflammation
D Togbe, L Fauconnier, F Madouri… - International …, 2013 - Wiley Online Library
Background. Thymic stromal lymphopoietin (TSLP) is induced in allergic skin and lung
inflammation in man and mice. Methods. Allergic lung inflammation induced by two …
inflammation in man and mice. Methods. Allergic lung inflammation induced by two …
Interleukin‐7 supports survival of T‐cell receptor‐β‐expressing CD4− CD8− double‐negative thymocytes
J Xiong, BL Parker, SL Dalheimer, TM Yankee - Immunology, 2013 - Wiley Online Library
Among the milestones that occur during T‐cell development in the thymus is the expression
of T‐cell receptor‐β (TCR‐β) and the formation of the pre‐TCR complex. Signals emanating …
of T‐cell receptor‐β (TCR‐β) and the formation of the pre‐TCR complex. Signals emanating …